Non-epithelial Tumors

  • BBSG – Brazilian Breast Study Group
  • Márcia Cristina Santos Pedrosa


The most common non-epithelial breast tumors are phyllodes tumor, sarcomas, and lymphoma. Clinical features may be similar to carcinoma, but they significantly differ in prognosis and treatment.


Phyllodes tumor Sarcoma Margins Breast lymphoma 

Recommended Reading

  1. 1.
    Onkendi EO, Jimenez RE, Spears GM, Harmsen WS, Ballman KV, Hieken TJ. Surgical treatment of borderline and malignant phyllodes tumors: the effect of the extent of resection and tumor characteristics on patient outcome. Ann Surg Oncol. 2014;21(10):3304–9. Retrospective analysis of 67 patients submitted to surgical treatment for phyllodes tumor (15 borderlines and 52 malignant) from 1971 to 2008 supported that the type of performed surgery and margin extension did not impact on disease-free survival. Predictive factors of higher recurrence rates were: tumors greater than 5 cm, mitosis rates> 10/10 HRA and stromal hyper-cellularity. CrossRefGoogle Scholar
  2. 2.
    Macdonald OK, Lee CM, Tward JD, et al. Malignant phyllodes tumor of the female breast: association of primary therapy with cause-specific survival from the Surveillance, Epidemiology, and End Results (SEER) program. Cancer. 2006;107(9):2127–33. 821 malignant phyllodes tumor patients were analysed from 1983 to 2002. Overall survival was 84% at 5 years, 77% at 10 years and 73% at 15 years. CrossRefGoogle Scholar
  3. 3.
    Guillot E, Couturaud B, Reyal F, et al. Management of phyllodes breast tumors. Breast J. 2011;17(2):129–37. A Curie Institute retrospective study encompassing 165 cases of phyllodes tumors followed between 1994 and 2008, with an average follow-up of 12.65 months. Conclusion: Histological grade and tumor size were the risk factors with statistical significance for local recurrence; a pronounced risk was demonstrated in borderline PT patients and large volume tumors. CrossRefGoogle Scholar
  4. 4.
    Barrio AV, Clark BD, Goldberg JI, et al. Clinicopathologic features and long-term outcomes of 293 phyllodes tumors of the breast. Ann Surg Oncol. 2007;14(10):2961–70. 293 PT patients from the Memorial Sloan-Kettering Cancer Center, with a mean follow-up of 7.9 years. Pathological features: large tumor volume (> 7 cm), infiltrating borders, significant stromal proliferation with increased stromal cellularity, high mitotic index and necrosis were associated to worse prognosis. 5 patients (71%) developed metastases within 1.5 years. CrossRefGoogle Scholar
  5. 5.
    Al-Benna S, Poggemann K, Steinau H, Steinstraesser L. Diagnosis and management of primary breast sarcoma. Breast Cancer Res Treat. 2010;122:619–26. Review of primary breast sarcoma. It highlights the prognosis importance of broad surgical margins. It should be emphasized that tumors larger than 5 cm or with positive margins may benefit from adjuvant QT or RT. CrossRefGoogle Scholar
  6. 6.
    Aviles A, Delgado S, Nambo MJ, et al. Primary breast lymphoma: results of a controlled clinical trial. Oncology. 2005;69:256–60. Single prospective study encompassing patients with primary breast lymphoma, evaluating the impact of therapy on overall survival and disease-free survival. It supports that combined radiotherapy and poly-chemotherapy (cisplatin, doxorubicin, vincristine and prednisone) is effective in improving overall survival and disease-free survival. CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • BBSG – Brazilian Breast Study Group
    • 1
  • Márcia Cristina Santos Pedrosa
    • 2
  1. 1.BBSGSao PauloBrazil
  2. 2.Breast SurgeryIMIP HospitalRecifeBrazil

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