Influence on Histologic, Immunohistochemical, and Molecular Subtypes on Therapeutics

  • BBSG – Brazilian Breast Study Group


Breast cancer is a heterogeneous disease that may be classified according to clinical, histopathological, immunohistochemical, and, more recently, molecular characteristics. The features of breast cancer gene expression led to the classification of tumors into distinct molecular subtypes. These subtypes present different clinical outcomes, including different responses to available therapies. The incorporation of gene signatures could better identify which patients may benefit from chemotherapy and the subtypes that have the best response to neoadjuvant chemotherapy. In this chapter, the main subgroups and their influence on therapy are described.


Systemic treatment Molecular subtype Genomic profile Disease burden 

Recommended Reading

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • BBSG – Brazilian Breast Study Group
    • 1
  1. 1.BBSGSao PauloBrazil

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