Autologous Fat Grafting in the Breast: Lipofilling

  • BBSG – Brazilian Breast Study Group


The use of autologous fat for correction of body contour defects is not new. The first descriptions date from the end of the nineteenth century, and in the twentieth century this procedure became widely used, mainly in surgical procedures of the hands and the face. The use of this technique in the breast began to be considered in the 1980s, stimulated by the advent of liposuction for aesthetic purposes.


Lipofilling  Fat grafting  Oncological safety  Aesthetical outcomes  Oncoplastic techniques 

Recommended Readings

  1. 1.
    Coleman SR. Structural fat grafting: more than a permanent filler. Plast Reconstr Surg. 2006;118(3 Suppl):108S–20S. A classic Coleman article in which the technique is reviewed and long-term breast lipoxygenase data are presented, with emphasis on the efficacy of the method in healthy breasts. CrossRefGoogle Scholar
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    Gutowski KA. ASPS fat graft task force. Current applications and safety of autologous fat grafts: a report of the ASPS fat graft task force. Plast Reconstr Surg. 2009;124(1):272–80. Review article of the American Society of Plastic Surgery regarding the applicability of lipofilling in the breast. It deals with different techniques, effectiveness and safety evidence. The ASPS authorizes the accomplishment of lipofilling provided that informed consent is made. In patients at high risk for breast cancer or with a history of breast cancer, although there is no negative evidence, it suggests that this type of patient be conducted within clinical studies. CrossRefGoogle Scholar
  3. 3.
    Lohsiriwat V, Curigliano G, Rietjens M, Goldhirsch A, Petit JY. Autologous fat transplantation in patients with breast cancer: “silencing” or “fueling” cancer recurrence? Breast. 2011;20(4):351–7. Review article on basic research on the interaction between adipocytes, ADSC, normal cells and tumor mammary cells. There are factors that associate ADSC with the stimulation of tumor cells and others that would provoke inhibition effects. Interaction in humans should be investigated. CrossRefGoogle Scholar
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    Schweizer R, Tsuji W, Gorantla VS, Marra KG, Rubin JP, Plock JA. The role of adipose-derived stem cells in breast cancer progression and metastasis. Stem Cells Int. 2015. Epub 2015 Apr 27. Systematic review of 28 in vitro experimental studies and animal models evaluating the interaction between ADSC and cancer cells. All studies demonstrate accelerated growth of tumor cells, as well as faster growth of induced breast tumors in the models and metastasization. Google Scholar
  5. 5.
    Waked K, Colle J, Doornaert M, Cocquyt V, Blondeel P. Systematic review: the oncological safety of adipose fat transfer after breast cancer surgery. Breast. 2017;31:128–36. Systematic review of more than 100 articles, 18 prospective clinical studies and cohorts of patients with a history of breast cancer undergoing lipofilling were selected. There was no increase in recurrences in the lipofilling group. Despite the encouraging result, there are no prospective randomized studies. Avoid lipofilling in patients at high risk for local recurrence must be considered. CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • BBSG – Brazilian Breast Study Group
    • 1
  1. 1.BBSGSao PauloBrazil

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