Prevention: Chemoprevention (Primary Prevention of Breast Cancer)

  • BBSG – Brazilian Breast Study Group


In 1976, Sporn defined chemoprevention as the use of natural or pharmacological agents that inhibit the development of invasive breast carcinoma by blocking changes in DNA that would initiate carcinogenesis or by preventing and reversing the progression of already present precursor lesions. Proven and well-established methods block estrogenic action in the breast through the use of SERMs (Selective Estrogen Receptor Modulators) or aromatase inhibitors.

Leitura Recomendada

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    Cuzick J, Sestak I, Forbes JF, Dowsett M, Knox J, Cawthorn S, et al. Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): an international, double-blind, randomised placebo-controlled trial. Lancet. 2014;383:1041–8. A randomized, double-blind study of 3864 high-risk postmenopausal women randomized for anastrozole or placebo use for five years. After a seven-year follow-up, 50% reduction in breast cancer was observed in the experimental group. The main side effects were related to the osteoarticular system.CrossRefGoogle Scholar
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    Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst. 1998;90(18):1371–88. 1st randomized placebo-controlled clinical trial of chemoprevention. The study evaluated 13,338 women, mainly at high risk. After five years, a 48% reduction in the incidence of breast cancer was observed, but there was no reduction in mortality. Increased endometrial carcinoma, cataract, and DVT /PET were observed.CrossRefGoogle Scholar
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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • BBSG – Brazilian Breast Study Group
    • 1
  1. 1.BBSGSao PauloBrazil

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