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Procedure for Cases of Intraductal and Proliferative Lesions

  • BBSG – Brazilian Breast Study Group
Chapter

Abstract

The adequate classification of proliferative lesions is important because of its association with the risk of developing invasive breast carcinoma, especially when diagnosed between 35 and 55 years of age. Several criteria have already been described for the classification of atypical hyperplasias of ductal and lobular patterns, without a definite consensus among the authors, although there is common agreement that they share similar risks for the development of invasive breast carcinoma. The importance of histopathological differentiation of atypical ductal hyperplasias with low-grade ductal carcinoma in situ (DCIS) is emphasized, which requires a completely different treatment.

Recommended Reading

  1. 1.
    Ellis IO. Intraductal proliferative lesions of the breast: morphology, associated risk and molecular biology. Modern Pathology. 2010;23:S1–7. Review of the main morphological aspects of ductal proliferative lesions, and suggestion of management of these lesionsCrossRefGoogle Scholar
  2. 2.
    Fisher ER, Land S, Fisher B, Mamounas E, Gilarski L, Wolmark N. Pathologic findings from the national surgical adjuvant breast and bowel project. Twelve-year observations concerning lobular carcinoma in situ. Cancer. 2004;15(100):238–44. Study of 182 patients with LN. After 12 years, 10.5% of invasive carcinoma (contralateral: 5.0%, ipsilateral: 5.5%). All local invasive relapses occurred at the site of the primary lesion. Interpretation: LN is a precursor lesion of breast cancer, but quite indolentCrossRefGoogle Scholar
  3. 3.
    Ho CSB, Tan PH. Atypical hiperplasia and in situ breast carcinona – lobular neoplasia of the breast: 68 years on. Pathology. 2009;41(1):28–5. The adoption of different classifications represents the difficulty in choosing the correct classification of these lesions and the inter-observer variability describedCrossRefGoogle Scholar
  4. 4.
    O’Malley FP. Lobular neoplasia: morphology, biological potential and management in core biopsies. Mod Pathol. 2010;23:S14–25. Review of the main morphological aspects of ductal proliferative lesions, and suggestion of management of these lesionsCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • BBSG – Brazilian Breast Study Group
    • 1
  1. 1.BBSGSao PauloBrazil

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