Classification of Intraductal Precursor and Proliferative Lesions
Proliferative epithelial lesions or mammary epithelial hyperplasia comprises a heterogeneous spectrum of alterations confined to the ductal-lobular system. These lesions are divided into two major categories, ductal and lobular, based on cytological and architectural criteria, meaning no specific origin in ducts or lobes. The new Classification of Breast Tumors of the World Health Organization (WHO) 2012 (Table 1) adopted the classic or traditional terminology of intraductal proliferative lesions and did not recommend the nomenclature of “mammary intraductal neoplasia”proposed by Tavassoli. According to WHO, the concept and terminology of intraductal proliferative lesions should be viewed as an evolving process, which may be modified when new molecular and genetic data are incorporated into the classification of these lesions.
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