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Histologic Variants of Acinar Adenocarcinoma, Ductal Adenocarcinoma, Neuroendocrine Tumors, and Other Carcinomas

  • Rajal B. ShahEmail author
  • Ming Zhou
Chapter

Abstract

Histologic variants of prostate acinar adenocarcinoma, ductal adenocarcinoma, neuroendocrine tumors, and other carcinomas account for 5–10% of prostate carcinomas and frequently are associated with ordinary acinar prostate adenocarcinoma. The morphologic spectrum of histologic variants of acinar adenocarcinoma ranges from tumors often resembling benign conditions, such as foamy and pseudohyperplastic carcinoma, to highly aggressive forms, such as sarcomatoid carcinoma. These histologic variants of acinar adenocarcinoma, ductal adenocarcinoma, neuroendocrine tumors, and other carcinomas often differ from acinar carcinoma in clinical, immunophenotypic, ultrastructural, or genetic features. Some of this histologic spectrum also differ in prognosis and may necessitate a different therapeutic approach. This chapter outlines important clinical and pathologic characteristics of histologic variants of acinar adenocarcinoma, ductal adenocarcinoma, neuroendocrine tumors, and other carcinomas.

Keywords

Prostate adenocarcinoma Histologic variants of acinar adenocarcinoma WHO classification of histologic variants of acinar adenocarcinoma Atrophic adenocarcinoma Pseudohyperplastic carcinoma Microcystic carcinoma Foamy gland carcinoma Mucinous (colloid) carcinoma Signet ring cell-like carcinoma Pleomorphic giant cell carcinoma Sarcomatoid carcinoma PIN-like adenocarcinoma PIN-like ductal carcinoma Ductal adenocarcinoma Neuroendocrine prostate cancer NEPC Well-differentiated neuroendocrine tumor Carcinoid tumor Small-cell neuroendocrine carcinoma Large cell neuroendocrine carcinoma Mixed neuroendocrine carcinoma Treatment-emergent transformed neuroendocrine cancer Squamous and adenosquamous carcinoma Basal cell carcinoma Urothelial carcinoma Cowper’s glands Mucinous metaplasia Xanthomatous inflammation Benign atrophy Partial atrophy Postatrophic hyperplasia Benign prostatic hyperplasia BPH Prostatic intraepithelial neoplasia (PIN) 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Robert J Tomsich Pathology and Laboratory Medicine InstituteCleveland ClinicClevelandUSA
  2. 2.Tufts Medical CenterBostonUSA

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