Treatment Effect in Benign and Malignant Prostate Tissue

  • Rajal B. ShahEmail author
  • Ming Zhou


Prostate lesions are managed by surgical and nonsurgical modalities, including observation, active surveillance, surgical resection, ablation by physical methods such as cryoablation and thermal ablation, and drugs that target the androgen pathways. Treatment may cause significant changes in morphology of both benign and malignant prostate tissues. Such changes may pose a significant challenge in diagnosis and grading of prostate cancer, particularly in needle biopsy specimens. In addition, prostate cancer with treatment effect should not be Gleason-graded as therapy-induced architectural changes, upon which Gleason grading is based, are not indicative of its biological behavior. Treatment history is, however, not always provided by clinicians. Therefore, pathologists should be aware of the histological changes associated with treatments in benign and malignant prostate tissue.


Treatment effect Radiation Total androgen blockade First-generation antiandrogen Second-generation antiandrogen Aromatase inhibitor Laser ablation Cryoablation Benign prostate tissue Malignant prostate tissue Treatment modalities for prostate lesions Histological changes Androgen deprivation Mucin lake Foamy histiocytes Cryotherapy Hyperthermia Grading radiation effect 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Robert J Tomsich Pathology and Laboratory Medicine InstituteCleveland ClinicClevelandUSA
  2. 2.Tufts Medical CenterBostonUSA

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