Spindle Cell Lesions of the Prostate Gland

  • Rajal B. ShahEmail author
  • Ming Zhou


Spindle cell lesions of the prostate are encountered infrequently in clinical practice but represent a broad spectrum of diagnostically challenging lesions with varying clinical significance. The spindle cell lesions encompass both primary and secondary processes. A subset of these lesions is thought to be derived from the hormone-responsive stroma of the prostate gland, including stromal hyperplasia, stromal tumors of uncertain malignant potential (STUMP), and prostate stromal sarcoma (PSS). The utility of ancillary studies, including immunohistochemistry, is often limited, and the diagnosis relies on careful morphological evaluation.


Spindle cell lesions Stromal hyperplasia Stromal tumors of uncertain malignant potential STUMP Prostate stromal sarcoma PSS Solitary fibrous tumor SFT STAT6 Sclerosing adenosis Smooth muscle neoplasms Leiomyoma Leiomyosarcoma Inflammatory myofibroblastic tumor IMT Myofibroblastic proliferation Postoperative spindle cell tumor ALK-1 Rhabdomyosarcoma Gastrointestinal stromal tumor GIST CKIT DOG-1 Sarcomatoid carcinoma Schwannoma Transurethral resection of the prostate TURP 


  1. 1.
    Cheville J, Algaba F, Epstein JI, et al. Mesenchymal tumours. In: Moch H, Humphrey PA, Ulbright TM, et al., editors. WHO classification of tumours of the urinary system and male genital organs. Lyon: IARC Press; 2016. p. 175–7.Google Scholar
  2. 2.
    McKenney JK. Mesenchymal tumors of the prostate. Mod Pathol. 2018;31:S133–42.CrossRefGoogle Scholar
  3. 3.
    Bostwick DG, Hossain D, Qian J, Neumann RM, Yang P, Young RH, et al. Phyllodes tumor of the prostate: long-term followup study of 23 cases. J Urol. 2004;172:894–9.CrossRefGoogle Scholar
  4. 4.
    Herawi M, Epstein JI. Specialized stromal tumors of the prostate: a clinicopathologic study of 50 cases. Am J Surg Pathol. 2006;30:694–704.CrossRefGoogle Scholar
  5. 5.
    Sexton WJ, Lance RE, Reyes AO, Pisters PW, Tu SM, Pisters LL. Adult prostate sarcoma: the M. D. Anderson Cancer Center experience. J Urol. 2001;166:521–5.CrossRefGoogle Scholar
  6. 6.
    Cheah AL, Billings SD, Goldblum JR, Carver P, Tanas MZ, Rubin BP. STAT6 rabbit monoclonal antibody is a robust diagnostic tool for the distinction of solitary fibrous tumour from its mimics. Pathology. 2014;46:389–95.CrossRefGoogle Scholar
  7. 7.
    Guner G, Bishop JA, Bezerra SM, Taheri D, Zahavi DJ, Mendoza Rodriguez MA, et al. The utility of STAT6 and ALDH1 expression in the differential diagnosis of solitary fibrous tumor versus prostate-specific stromal neoplasms. Hum Pathol. 2016;54:184–8.CrossRefGoogle Scholar
  8. 8.
    Herawi M, Montgomery EA, Epstein JI. Gastrointestinal stromal tumors (GISTs) on prostate needle biopsy: a clinicopathologic study of 8 cases. Am J Surg Pathol. 2006;30:1389–95.CrossRefGoogle Scholar
  9. 9.
    Hansel DE, Herawi M, Montgomery E, Epstein JI. Spindle cell lesions of the adult prostate. Mod Pathol. 2007;20:148–58.CrossRefGoogle Scholar
  10. 10.
    McKenney JK. An approach to the classification of spindle cell proliferations in the urinary bladder. Adv Anat Pathol. 2005;12:312–23.CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Robert J Tomsich Pathology and Laboratory Medicine InstituteCleveland ClinicClevelandUSA
  2. 2.Tufts Medical CenterBostonUSA

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