Mesenchymal Neoplasms

  • Aysegul Sari
  • Richard Kirsch
  • James Conner
Part of the Atlas of Anatomic Pathology book series (AAP)


As in the stomach, gastrointestinal stromal tumors (GIST) comprise the majority of malignant mesenchymal neoplasms in the small and large intestine. In addition, there is a diverse array of other nonepithelial tumors, both benign and malignant. Many benign mucosal and submucosal mesenchymal neoplasms may present as colorectal polyps, and recognition of these entities can be useful in some situations to explain the endoscopic impression of a polyp in the absence of typical adenomatous or hyperplastic epithelial changes. Some mesenchymal lesions are entirely harmless in isolation but may indicate the presence of an underlying hereditary cancer syndrome. Recognizing these associations and flagging appropriate patients may prompt clinical genetic evaluation and modification of cancer surveillance protocols. This chapter reviews key histologic features of the most common mesenchymal neoplasms in the small and large intestine.


Gastrointestinal stromal tumor GIST Smooth muscle tumors Mesenchymal polyps Tumors of fibroblastic origin Tumors of myofibroblastic origin Sarcoma Pseudosarcoma Carcinoma 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Aysegul Sari
    • 1
    • 2
  • Richard Kirsch
    • 1
  • James Conner
    • 1
  1. 1.Department of Pathology and Laboratory MedicineMount Sinai Hospital, University of TorontoTorontoCanada
  2. 2.İzmir Katip Celebi University Ataturk Training and Research HospitalİzmirTurkey

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