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Medical Management of LPR

  • Justin Field
  • Deena Midani
  • Yellowlees Douglas
  • Michael S. Smith
Chapter

Abstract

Laryngopharyngeal reflux (LPR) is a disorder that may cause a variety of symptoms, including dysphagia, chronic cough, postnasal drip, hoarseness, and fatigue. These symptoms stem from gastroesophageal reflux disease (GERD), which is far more widely studied and also offers multiple treatment modalities compared to the understudied LPR. These approaches prove particularly relevant for patients who have failed lifestyle modifications and include pharmacotherapy ranging from proton-pump inhibitors and histamine-2 receptor antagonists to GABAB agonists and neuromodulators. In addition, relatively new and minimally invasive endoscopic techniques for addressing LPR include transoral incisionless fundoplication, radiofrequency ablation of the lower esophageal sphincter, and anterior fundoplication, any of which may provide patients with relief from symptoms of LPR.

Keywords

Laryngopharyngeal reflux Gastroesophageal reflux disease Proton-pump inhibitors Prokinetics Neuromodulators Endoscopic fundoplication 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Justin Field
    • 1
  • Deena Midani
    • 2
  • Yellowlees Douglas
    • 3
  • Michael S. Smith
    • 4
  1. 1.Division of Gastroenterology and Hepatology, Department of MedicineMount Sinai Beth Israel, Mount Sinai West and Mount Sinai St. Luke’s HospitalsNew YorkUSA
  2. 2.Gastroenterology, Cedars-Sinai Medical GroupLos AngelesUSA
  3. 3.Independent ResearcherBrooklynUSA
  4. 4.Division of Gastroenterology and Hepatology, Department of MedicineMount Sinai West and Mount Sinai St. Luke’s HospitalsNew YorkUSA

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