Initial orthodontic alignment typically represents the first phase of fixed appliance-based treatment. The objectives of this stage include correction of horizontal and rotational discrepancies (alignment), improvement of gross angulation and inclination issues and vertical correction (levelling) between adjacent teeth. Ultimately, this involves alignment of the bracket slots relative to each other permitting progression into larger dimension and stiffer wires at later treatment stages when other objectives such as overjet reduction and space closure can be achieved. In contemporary treatment, overbite reduction is increasingly undertaken in tandem with alignment; however, the specifics of overbite reduction will be described in Chap. 6.