Electro-Thermal Characterization and Modeling of a 4-Wire Microheater for Lab-on-Chip Systems

  • Andrea Scorzoni
  • Pisana PlacidiEmail author
  • Paolo Valigi
  • Nicola Lovecchio
Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 573)


The paper proposes a part of an extended research devoted to the application of Lab-on-Chip systems for the detection of viral infections. The focus is on accurate lumped element modeling, simulation and experimental characterization of the thermal behavior of an integrated glass micro-heater, useful for the design and simulation of dedicated electronic controlling systems. A lumped three-compartment model for the analysis of the thermal behavior of a heater has been proposed and discussed. The mathematical model was extensively simulated, and the associated parameters have been chosen in order to minimize the L2 norm of the error with respect to experimental data collected though an experiment campaign.



This work has been carried out in the framework of the “Fondo di Ricerca di Base 2018”, funded by the University of Perugia (Project n.o.: PJ RICBA18PP). The authors would like to thank prof. G. de Cesare and the DIET group for samples preparation and their suggestions.


  1. 1.
    Shagun, G., Kritika, R., Suhaib, A., Vipan K.: Lab-on-Chip technology: a review on design trends and future scope in biomedical applications. Int. J. Bio-Sci. Bio-Technol. 8(5), 311–322 (2016)Google Scholar
  2. 2.
    Richard, B.F., et al.: Chemical and biological applications of digital-microfluidic devices, chemical and biological applications of digital-microfluidic devices. IEEE Des. Test Comput. 24(1), 10–24 (2007)CrossRefGoogle Scholar
  3. 3.
    Francesca, C., et al.: Integrated sensor system for DNA amplification and separation based on thin film technology. IEEE Trans. Compon. Packag. Manuf. Technol. 8(7), 1141–1148 (2018)Google Scholar
  4. 4.
    Scorzoni, A., et al.: Thermal characterization of a thin film heater on glass substrate for lab-on-chip applications. In: Proceedings of I2MTC, pp. 1089–1094 (2014)Google Scholar
  5. 5.
    Mejer, G.C.M. (ed.): Smart Sensor Systems. Wiley (2008)Google Scholar
  6. 6.
    Scorzoni, A., Tavernelli, M., Placidi, P., Valigi, P., Nascetti, A.: Accurate analog temperature control of a thin film microheater on glass substrate for lab-on-chip applications. In: Proceedings of the IEEE Sensors Conference, November 2–5, 2014, Valencia, Spain (2014)Google Scholar
  7. 7.
    Caputo, D., de Cesare, G., Nascetti, A., Scipinotti, R.: A-Si: H temperature sensor integrated in a thin film heater. Phys. Status Solidi A 207(3), 708–711 (2010)CrossRefGoogle Scholar
  8. 8.
    Lahlalia, A., Filipovic, L., Selberherr, S.: Modeling and simulation of novel semiconducting metal oxide gas sensors for wearable devices. IEEE Sens. J. 18(5), 1960–1970 (2018)CrossRefGoogle Scholar
  9. 9.
    Sripumkhai, W., et al.: On-chip platinum micro-heater with platinum temperature sensor for a fully integrated disposable PCR module. Adv. Mater. Res. 93–94, 129–132 (2010)CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Andrea Scorzoni
    • 1
  • Pisana Placidi
    • 1
    Email author
  • Paolo Valigi
    • 1
  • Nicola Lovecchio
    • 2
  1. 1.Dipartimento di IngegneriaPerugiaItaly
  2. 2.DIET, Sapienza University of RomeRomeItaly

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