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Stem Cell Therapy for Liver Diseases

  • Dimitra ZagouraEmail author
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

Liver diseases consist a growing health problem and one of the most serious causes of death worldwide. Liver transplantation is an established and successful procedure that represents the only gold standard therapy for a wide variety of liver diseases refractory to medical treatment. Despite its therapeutic potential, it remains a non-specific approach that is limited by donor organ shortage and a lifelong immunosuppressive therapy with its specific risks. Recently, liver cell therapy has focused on the hepatoprotective potential of stem cells via restoration of normal function, after tissue injury and regulation of the inflammatory processes in preclinical disease models.

This chapter provides a description of the current issues on stem cell-based regenerative opportunities for liver diseases. In more detail, there will be discussed thoroughly the different stem cell sources and their clinical applications in in vivo rodent models and in patients with liver failure.

Keywords

Stem cells Differentiation Hepatocyte-like cells Liver therapy Paracrine effect 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Laboratory of Biology, Medical School of AthensNational and Kapodistrian University of AthensAthensGreece

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