Lymphoid Follicles: Reactive vs. Neoplastic
Lymphoid follicles are not native to the skin, and their presence in the dermis is a pathologic finding. They can be reactive (benign) or neoplastic (malignant) and can be present in several types of pseudolymphoma and in low-grade cutaneous B-cell lymphomas. The distinguishing histomorphologic features include their distribution, mantle zone preservation, mitotic activity, tingible body macrophages, and polarization.
KeywordsLymphoid Follicles Reactive Neoplastic Germinal center Histopathology
- Subtil A. A general approach to the diagnosis of cutaneous lymphomas and pseudolymphomas. Cutaneous lymphomas (Subtil, ed.). Surg Pathol Clin. 2014;7(2):135–42. Elsevier: Philadelphia.Google Scholar