Disease Modification in Crohn’s Disease

  • Patrick B. Allen
  • Laurent Peyrin-Biroulet


Crohn’s disease (CD) is a chronic inflammatory disease of the gastrointestinal tract (GIT) that evolves in a relapsing and remitting pattern. CD is a destructive disease that can result in progressive bowel damage and ultimately disability. It mainly affects young adults, causes morbidity, and impacts on quality of life. The majority of patients with CD initially present with an inflammatory phenotype at diagnosis, but over time various complications that result in tissue damage can occur such as strictures, abscesses, and fistulae, which often require surgery. The functional correlate of tissue damage is disability which may develop over time. Current management strategies therefore base their premise on “treating to target” with the aim of achieving deep and prolonged disease remission, thereby preventing tissue damage and disability. The following sections will address the identification and assessment of tissue damage and how we can evaluate disability in CD.


Crohn’s disease Inflammatory bowel disease Disability Quality of life Biologics Immunosuppressants Disease modification Treat to target Deep remission 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Patrick B. Allen
    • 1
    • 2
  • Laurent Peyrin-Biroulet
    • 3
  1. 1.Department of Medicine and GastroenterologyUlster HospitalBelfastUK
  2. 2.South Eastern Health and Social Care TrustBelfastUK
  3. 3.Department of Hepato-Gastroenterology and Inserm U954University Hospital of Nancy, Lorraine UniversityVandoeuvre-lès-NancyFrance

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