Exposome and Diet

  • Jakob Seidelin
  • Johan Burisch


The underlying etiopathogenic factor for inflammatory bowel disease (IBD) remains unclear. It is generally accepted that IBD results from a complex relationship between genetic susceptibility, environmental factors, and intestinal microbiota, resulting in a self-perpetuating abnormal mucosal immune response. While several environmental factors have been associated with the onset of IBD, to date no specific environmental/microbial causative factors have been identified. Less is known about the influence of the exposome, the sum of all environmental exposures faced by a human being during his life, on the disease course in established IBD. In this chapter we summarize what is known about the influence of environmental exposures such as lifestyle factors, drugs, appendectomy, infections, diet, and external factors such as altitude and pollution. We demonstrate how the influence of the exposome on disease course remains poorly investigated and understood underlining the need for more clinical epidemiological and mechanistic research.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Jakob Seidelin
    • 1
  • Johan Burisch
    • 2
  1. 1.Department of GastroenterologyHerlev University HospitalHerlevDenmark
  2. 2.Department of GastroenterologyNorth Zealand University HospitalFrederikssundDenmark

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