Histological Changes Associated with Fetal Maceration
The collective changes that occur in the fetal organs and tissues after fetal death in utero are referred to as maceration changes; they differ from pure postmortem autolysis because they occur in utero, in fluid, and at body temperature. The changes of maceration are therefore commonly encountered by the pathologist performing fetal autopsies and examining fetal tissues at the surgical pathology bench. This chapter reviews how the histologic fetal and placental changes of maceration can be used to predict the timing of fetal death in utero, discuss histologic artifacts introduced by maceration, and describe the challenges of assessing pathologic changes in a background of maceration.
KeywordsFetus papyraceous Involutional changes Loss of nuclear basophilia Timing of intrauterine death
- 1.“Macerate.” Merriam-Webster, www.merriam-webster.com/dictionary/macerate. Accessed 25 Apr 2018.
- 9.Royal College of Obstetricians and Gynaecologists and Royal College of Pathologists. Fetal and perinatal pathology: report of a joint working party. London: Royal College of Obstetricians and Gynaecologists; 2001. p. 1–38.Google Scholar