Surgery for Cushing’s Disease

  • Brooke SwearingenEmail author
Part of the Contemporary Endocrinology book series (COE)


Transsphenoidal surgery is considered a first-line therapy for Cushing’s disease in children. Preoperative evaluation includes appropriate biochemical testing, MRI imaging, and inferior petrosal sinus sampling, to confirm a pituitary source. Remission rates between 50% and 95% have been reported in various series, depending on the size and invasiveness of the tumor, with acceptably low surgical morbidity. Recurrence remains an issue despite initial indications of remission, and adjunctive therapy, including radiosurgery, medical treatment, and adrenalectomy, is sometimes required.


Pediatric Cushing’s disease Transsphenoidal surgery Inferior petrosal sinus sampling 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of NeurosurgeryMassachusetts General HospitalBostonUSA

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