Genetics of Hypopituitarism

  • Mariam GangatEmail author
  • Sally Radovick
Part of the Contemporary Endocrinology book series (COE)


This review will summarize pituitary development and function, as well as review defects in transcription factor genes PROP1 and POU1F1, which play a critical role in pituitary cell differentiation. These selected factors have been well described in patients with hypopituitarism and therefore are very relevant to clinical practice.


Pituitary development Transcription factor Combined pituitary hormone deficiency PROP1 POU1F1 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Pediatric EndocrinologyRutgers – Robert Wood Johnson Medical SchoolNew BrunswickUSA
  2. 2.Department of PediatricsRutgers – Robert Wood Johnson Medical SchoolNew BrunswickUSA

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