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Towards Automated Multiscale Imaging and Analysis in TEM: Glomerulus Detection by Fusion of CNN and LBP Maps

  • Elisabeth WetzerEmail author
  • Joakim Lindblad
  • Ida-Maria Sintorn
  • Kjell Hultenby
  • Nataša Sladoje
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11134)

Abstract

Glomerulal structures in kidney tissue have to be analysed at a nanometer scale for several medical diagnoses. They are therefore commonly imaged using Transmission Electron Microscopy. The high resolution produces large amounts of data and requires long acquisition time, which makes automated imaging and glomerulus detection a desired option. This paper presents a deep learning approach for Glomerulus detection, using two architectures, VGG16 (with batch normalization) and ResNet50. To enhance the performance over training based only on intensity images, multiple approaches to fuse the input with texture information encoded in local binary patterns of different scales have been evaluated. The results show a consistent improvement in Glomerulus detection when fusing texture-based trained networks with intensity-based ones at a late classification stage.

Keywords

Glomerulus detection Transmission Electron Microscopy Convolutional Neural Networks Local binary patterns Digital pathology 

Notes

Acknowledgment

This work is supported by VINNOVA, MedTech4Health grants 2016-02329 and 2017-02447, the Ministry of Education, Science, and Techn. Development of the Rep. of Serbia (proj. ON174008 and III44006), and the Centre for Interdisciplinary Mathematics, Uppsala University.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Uppsala UniversityUppsalaSweden
  2. 2.Karolinska InstituteSolnaSweden
  3. 3.Vironova ABStockholmSweden
  4. 4.Mathematical Institute of Serbian Academy of Sciences and ArtsBelgradeSerbia

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