Oral Cavity

  • Sasha Jane Betz
  • Ricardo J. Padilla
Part of the Practical Anatomic Pathology book series (PAP)


The oral cavity is the primary entry point for exogenous substances into the body and home to the specialized tissues that help us chew, taste, speak, and express ourselves. Lesions that occur in the soft tissues of the mouth may be caused by traumatic injury, antigenic or carcinogenic exposures, odontogenic infections, or manifestations of systemic diseases. In this chapter, we will address lesions arising from these different etiologies with attention to the systemic implications of intraoral findings.


Papillary Verrucous Human papillomavirus Squamous papilloma Multifocal epithelial hyperplasia Verruca vulgaris Condyloma acuminatum Verruciform xanthoma Inflammatory papillary hyperplasia Localized juvenile spongiotic gingival hyperplasia Squamous cell carcinoma Verrucous carcinoma Tori Exostoses Osseous choristoma Ectopic thyroid Dermoid cyst Pyogenic granuloma Infantile hemangioma Kaposi sarcoma Lymphatic malformation Venous malformation Arteriovenous malformation Caliber-persistent artery Varices Peripheral ossifying fibroma Peripheral giant cell granuloma Epulis fissuratum Multiple endocrine neoplasia Cowden syndrome Neurofibromatosis type 1 Tuberous sclerosis Amyloidosis Gingival hyperplasia Congenital epulis of the newborn Traumatic neuroma Mucosal neuroma Schwannoma Neurofibroma Solitary circumscribed neuroma Nerve sheath myxoma Angioleiomyoma Myofibroma Granular cell tumor Peutz-Jeghers syndrome Primary adrenal insufficiency Melanoacanthoma Mucosal melanoma Granulomatous inflammation Traumatic eosinophilic granuloma Lichenoid Lichen planus Vesiculo-erosive Pemphigus vulgaris Mucous membrane pemphigoid EBV-related ulcer Aphthous ulcer Intraoral herpes Submucous fibrosis Leukoplakia Dysplasia Genodermatosis Oral hairy leukoplakia Squamous odontogenic tumor p16 Geographic tongue Lymphoma Plasmacytoid Spindle cell malignancy Vesiculobullous 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Sasha Jane Betz
    • 1
  • Ricardo J. Padilla
    • 2
  1. 1.Naval Medical Center San Diego, Department of Anatomic PathologySan DiegoUSA
  2. 2.University of North Carolina School of Dentistry, Department of Diagnostic SciencesChapel HillUSA

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