Lactate in Critically Ill Patients: At the Crossroads Between Perfusion and Metabolism

  • M. Greco
  • A. Messina
  • M. CecconiEmail author
Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM)


Lactic acidosis is a common finding in critically ill patients, including patients with septic shock, cardiogenic or hypovolemic shock, trauma and liver failure [1–3]. In these conditions, hyperlactatemia occurs when production of lactic acid significantly exceeds lactate consumption. Lactate levels have been associated with patient outcomes in a large number of studies, either at patient admission or presentation or during the course of recovery [3–5]. In a study including more than 10,000 patients with septic shock, peak lactate concentration was associated with a near linear increase in patient mortality [6]. Outcome prediction was confirmed not only for absolute lactate values, but change in serum lactate levels was also independently associated with mortality [4].


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Anesthesia and Intensive CareHumanitas Clinical and Research Center - IRCCSMilanItaly

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