Squamous Cell Carcinoma

  • Mordechai Rosner
  • Ido Didi Fabian


Squamous cell carcinoma (SCC) is a malignancy that arises from the prickle–squamous cell layers of the epithelium. It can metastasize to regional lymph nodes and is potentially fatal. Most patients with SCC are 60 years of age or older. The main risk factors include ultraviolet light and actinic damage. Because of its variable clinical presentation, biopsy and histological examination are required for an accurate diagnosis. The main treatment modality is surgical excision, with microscopic monitoring of the margins or Mohs’ microsurgery. The treatment of choice for secondary orbital invasion is orbital exenteration. Keratoacanthoma is considered to be a variant of SCC.


Squamous cell carcinoma Keratoacanthoma Skin Eyelid Periocular Tumor Malignancy Perineural spread Ultraviolet Histopathology Epidermis Prickle cells Squamous cell layer Surgery Mohs’ microsurgery Sentinel lymph node biopsy Exenteration Radiation therapy Cryotherapy Chemotherapy Carbon dioxide laser Photodynamic therapy Retinoids α-Interferon Fluorouracil Imiquimod 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Mordechai Rosner
    • 1
  • Ido Didi Fabian
    • 2
  1. 1.Department of Ophthalmology, Eye Histopathology LaboratoryGoldschleger Eye Institute, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv UniversityTel AvivIsrael
  2. 2.Department of Ophthalmology, Ocular Oncology CenterGoldschleger Eye Institute, Sheba Medical Center, Sackler School of Medicine, Tel Aviv UniversityTel AvivIsrael

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