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Spiral Waves in the Heart

  • Alexander V. PanfilovEmail author
Chapter
Part of the The Frontiers Collection book series (FRONTCOLL)

Abstract

One of the most important applications of spiral waves is found in cardiology. Electrical waves in the heart which initiate cardiac contraction are similar to nonlinear waves in other excitable systems. In pathological situations they can form rotating spiral waves. Onset of spiral waves in the heart causes cardiac arrhythmias characterized by extremely fast and irregular heartbeat and can lead to cardiac arrest and sudden cardiac death. Although a general idea about the existence of spiral waves in the heart was proposed a long time ago, only recently it became possible to record them in experiment. In this chapter we provide the most known experimental examples of spiral wave activity in cardiac tissue. It includes experiments in slices of cardiac tissue, whole heart preparations and cultures of cardiac cells. We briefly describe properties of spiral waves in the heart and discuss how they differ from spiral waves in other excitable systems.

References

  1. 1.
    B.J. Caldwell, M.L. Trew, G.B. Sands, D.A. Hooks, I.J. LeGrice, B.H. Smaill, Three distinct directions of intramural activation reveal nonuniform side-to-side electrical coupling of ventricular myocytes. Circ. Arrhythm. Electrophysiol. 2, 433–440 (2009)CrossRefGoogle Scholar
  2. 2.
    J. Keener, J. Sneyd, Mathematical Physiology (Springer, New York, 1998)zbMATHGoogle Scholar
  3. 3.
    M.A. Allessie, F.I.M. Bonke, F.J.G. Schopman, Circus movement in rabbit atrial muscle as a mechanism of tachycardia. III. The leading circle concept: a new model of circus movement in cardiac tissue without the involvement of an anatomical obstacle. Circ. Res. 41, 9–18 (1977)Google Scholar
  4. 4.
    J.M. Davidenko, A.M. Pertsov, R. Salomonsz, W. Baxter, J. Jalife, Stationary and drifting spiral waves of excitation in isolated cardiac muscle. Nature 355, 349–351 (1992)ADSCrossRefGoogle Scholar
  5. 5.
    S.M. Narayan, D.E. Krummen, K. Shivkumar, P. Clopton, W.-J. Rappel, J.M. Miller, Treatment of atrial fibrillation by the ablation of localized sources. J. Am. Coll. Cardiol. 60, 628–636 (2012)CrossRefGoogle Scholar
  6. 6.
    R.A. Gray, A.M. Pertsov, J. Jalife, Spatial and temporal organization during cardiac fibrillation. Nature 392, 75–78 (1998)ADSCrossRefGoogle Scholar
  7. 7.
    S. Pandit, J. Jalife, Rotors and the dynamics of cardiac fibrillation. Circ. Res. 112, 849–862 (2013)CrossRefGoogle Scholar
  8. 8.
    E. Bourgeois, H. Reeves, J. Walcott, J. Rogers, Panoramic optical mapping shows wavebreak at a consistent anatomical site at the onset of ventricular fibrillation. Cardiovasc. Res. 93, 272–279 (2012)CrossRefGoogle Scholar
  9. 9.
    G. Bub, L. Glass, N. Publicover, A. Shrier, Bursting calcium rotors in cultured cardiac myocyte monolayers. Proc. Natl. Acad. Sci. USA 95, 10283–10287 (1998)ADSCrossRefGoogle Scholar
  10. 10.
    L. Hou, M. Deo, P. Furspan, S. Pandit, S. Mironov, D. Auerbach, Q. Gong, Z. Zhou, O. Berenfeld, J. Jalife, A major role for hERG in determining frequency of reentry in neonatal rat ventricular myocyte monolayer. Circ. Res. 107, 1503–1511 (2010)CrossRefGoogle Scholar
  11. 11.
    I. Feola, L. Volkers, R. Majumder, A. Teplenin, M. Schalij, A. Panfilov, A. de Vries, D. Pijnappels, Localized optogenetic targeting of rotors in atrial cardiomyocyte monolayers. Circ. Arrhythm. Electrophysiol. 10, e005591 (2017)CrossRefGoogle Scholar
  12. 12.
    W.-J. Rappel, J. Zaman, S. Narayan, Mechanisms for the termination of atrial fibrillation by localized ablation: computational and clinical studies. Circ. Arrhythm. Electrophys. 8, 1325–1333 (2015)CrossRefGoogle Scholar
  13. 13.
    R. Burton, A. Klimas, C. Ambrosi, J. Tomek, A. Corbett, E. Entcheva, G. Bub, Optical control of excitation waves in cardiac tissue. Nat. Photonics 9, 813–816 (2015)ADSCrossRefGoogle Scholar
  14. 14.
    A.V. Panfilov, Theory of reentry, in Cardiac Electrophysiology: From Cell to Bedside, ed. by D.P. Zipes, J. Jalife, 5th edn. (Saunders Philadelphia 2009), pp. 329–337Google Scholar
  15. 15.
    A.V. Panfilov, H. Dierckx, Theory of rotors and arrhythmias, in Cardiac Electrophysiology: From Cell to Bedside, ed. by D.P. Zipes, J. Jalife, W.Stevenson, 7th edn. (Elsevier Philadelphia 2018), pp. 325–334Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Physics and AstronomyGent UniversityGentBelgium
  2. 2.Laboratory of Experimental Cardiology, Department of Cardiology, Heart Lung CenterLeiden University Medical CenterLeidenThe Netherlands

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