Fabrication Methods of Sustainable Hydrogels

  • Cédric Delattre
  • Fiona Louis
  • Mitsuru Akashi
  • Michiya Matsusaki
  • Philippe Michaud
  • Guillaume PierreEmail author


The interest received on hydrogels probably reflects one of the greatest challenges for the two last decades. Able to hold and release solvents and builds, these three-dimensional polymeric structures work as a network able to reversibly change in response to small physico-chemical modifications in their surroundings. Considering the fantastic amount of available techniques described in the literature, a brief overview of the fabrication methodology is synthesized from physical/chemical cross-linking or polymerization grafting to radiation cross-linking. Thus, this review explores the fabrication and recent applications of hydrogels in various fields including imaging, optics, diagnostics, drug delivery systems or tissue engineering. Extensive use of hydrogels raises some questions about life cycle assessment and how fabricating and/or using sustainable and innovative versions of the intelligent hydrogels of tomorrow.


Hydrogel Fabrication Sustainable Coating system Cross-linking Polysaccharide 

List of Abbreviations


Two dimensions


Three dimensions/three dimensional


Four dimensional


Acrylic acid




Adipose-derived stem cells


Bone morphogenetic proteins 2


Cell coating


Confocal laser scanning microscopy


Dulbecco’s modified eagle medium


Extracellular matrices


Ethyl carbodiimide


Ethylene glycol


Ethylene glycol dimethacrylate


Fetal bovine serum






Hydroxyethyl methacrylate


Human umbilical vein endothelial cells


Interpenetrating polymeric


Induced pluripotent stem cell-derived cardiomyocytes




Life-cycle assessment


Lymph epithelial cells


Bone marrow stromal cells


Maleic chitosan derivatives




Normal human dermal fibroblasts




Phosphate buffer saline


Poly(ethylene glycol)


Poly(ethylene glycol) diacrylate


Poly(lactic-co-glycolic acid)


Polyacrylamide particle gels


Poly(propylene oxide)-poly(ethylene oxide)


Poly (vinyl) alcohol


Poly (vinyl pyrrolidone)


Poly-vinylsulfonic acid


Arginine-glycine-aspartic acid


Thiol-terminated poly (vinyl alcohol)


Vinyl acetate



This research was supported by JST-PRESTO (15655131) and a Grant-in-Aid for Scientific Research (B) (26282138 and 17H02099). The authors also thank the program “Exploration Japon 2018” from Campus France, SST and SCAC (Ambassade de France au Japon).


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Cédric Delattre
    • 1
  • Fiona Louis
    • 2
  • Mitsuru Akashi
    • 3
  • Michiya Matsusaki
    • 2
    • 4
    • 5
  • Philippe Michaud
    • 1
  • Guillaume Pierre
    • 1
    Email author
  1. 1.Institut PascalUniversité Clermont Auvergne, CNRS, SIGMA ClermontClermont-FerrandFrance
  2. 2.Joint Research Laboratory (TOPPAN) for Advanced Cell Regulatory Chemistry, Graduate School of EngineeringOsaka UniversitySuitaJapan
  3. 3.Department of Frontier Biosciences, Graduate School of Frontier BiosciencesOsaka UniversitySuitaJapan
  4. 4.Department of Applied Chemistry, Graduate School of EngineeringOsaka UniversitySuitaJapan
  5. 5.JST-PRESTOKawaguchiJapan

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