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Introduction: Why (Another) Book on Vitamin E?

  • Peter WeberEmail author
  • Marc Birringer
  • Jeffrey B. Blumberg
  • Manfred Eggersdorfer
  • Jan Frank
Chapter
Part of the Nutrition and Health book series (NH)

Vitamin E is a well-described, fat-soluble essential micronutrient and, as such, must be provided to the human body on a regular basis to prevent deficiency symptoms and maintain a healthy status. As vitamin E was discovered close to a century ago, there is a wealth of data about this vitamin in the public domain, reported in original research articles and reviews as well as in many books addressing its mechanisms of action and preclinical investigations as well as its benefits and safety profiles in human studies. So, one may ask: Why another book on vitamin E?

Despite the huge body of evidence about vitamin E accumulated over time, many issues remain unsettled, and inconsistent study results always pose new questions. However, the scientific progress we have experienced over the last decade has provided new insights into the mode(s) of action of vitamin E and the biological roles of individual tocopherol and tocotrienol congeners that shed new light on the roles of vitamin E in human...

References

  1. 1.
    IOM. Vitamin E. In: Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington, DC: National Academies Press (US); 2000. p. 186–283.Google Scholar
  2. 2.
    EFSA NDA Panel (EFSA Panel on Dietetic Products NaA). Scientific opinion on dietary reference values for vitamin E as α-tocopherol. EFSA J. 2015;13(7):4149.  https://doi.org/10.2903/j.efsa.2015.4149.CrossRefGoogle Scholar
  3. 3.
    Nordic Nutrition Recommendations 2012. Integrating nutrition and physical activity. 5th ed. Arhus: Nordic Council of Ministers; 2014.  https://doi.org/10.6027/Nord2014-002.CrossRefGoogle Scholar
  4. 4.
    Milman U, Blum S, Shapira C, Aronson D, Miller-Lotan R, Anbinder Y, Alshiek J, Bennett L, Kostenko M, Landau M, Keidar S, Levy Y, Khemlin A, Radan A, Levy AP. Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2-2 genotype: a prospective double-blinded clinical trial. Arterioscler Thromb Vasc Biol. 2008;28:341–7.CrossRefGoogle Scholar
  5. 5.
    Blum S, Vardi M, Brown JB, Russell A, Milman U, Shapira C, Levy NS, Miller-Lotan R, Asleh R, Levy AP. Vitamin E reduces cardiovascular disease in individuals with diabetes mellitus and the haptoglobin 2-2 genotype. Pharmacogenomics. 2010;5:675–84.CrossRefGoogle Scholar
  6. 6.
    Blum S, Vardi M, Levy NS, Miller-Lotan R, Levy AP. The effect of vitamin E supplementation on cardiovascular risk in diabetic individuals with different haptoglobin phenotypes. Atherosclerosis. 2010;211:25–7.CrossRefGoogle Scholar
  7. 7.
    Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M, et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2018;67(1):328–57.CrossRefGoogle Scholar
  8. 8.
    EASL-EASD-EASO. Clinical practice guidelines for the management of non-alcoholic fatty liver disease. J Hepatol. 2016;64(6):1388–402.CrossRefGoogle Scholar
  9. 9.
  10. 10.
    Borel P, Desmarchelier C. Genetic variations involved in vitamin E status. 2016;17(12)  https://doi.org/10.3390/ijms17122094.
  11. 11.
    Chambers JD, Anderson JE, Salem MN, Bügel SG, Fenech M, Mason JB, Weber P, West KP Jr., Wilde P, Eggersdorfer M, Booth SL. The decline in vitamin research funding: a missed opportunity? Curr Dev Nutr. Oxford Press; 2017;1:e000430.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Peter Weber
    • 1
    Email author
  • Marc Birringer
    • 2
  • Jeffrey B. Blumberg
    • 3
  • Manfred Eggersdorfer
    • 4
  • Jan Frank
    • 1
  1. 1.Institute of Nutritional Sciences, University of HohenheimStuttgartGermany
  2. 2.University of Applied Sciences FuldaNutritional, Food and Consumer SciencesFuldaGermany
  3. 3.Friedman School of Nutrition Science and Policy, Jean Mayer USDA Human Nutrition Research Center on AgingTufts UniversityBostonUSA
  4. 4.University Medical Center GroningenHanzeplain 1GroningenThe Netherlands

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