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Advantages of the Eye as a Target Organ for Cell-Based Therapy in the Central Nervous System

  • Marco A. Zarbin
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

Advantages of the eye as a target organ for cell-based therapy are as follows. The anatomy and physiology of the retina have been characterized in detail. Surgical access to the vitreous cavity and the subretinal space are well established with an excellent safety record. The eye is an immune privileged organ, particularly the subretinal space, which may reduce the need for long-term immune suppression of transplant recipients. High-resolution noninvasive imaging technology permits visualization and functional assessment of the transplanted cells in situ. These imaging and monitoring capabilities permit development of an iterative pathway to successful transplant paradigms in human patients as well as precise modulation of immunotherapy should it be needed.

Keywords

Cell transplantation Retina Immune rejection Ocular imaging Retinal surgery Blindness 

Notes

Acknowledgements

Supported in part by the New Jersey Lions Eye Research Foundation, The Joseph J. and Marguerite DiSepio Research Fund, The Eng Family Fund for Excellence in Ophthalmology, and Robert and Patty Wigder.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Marco A. Zarbin
    • 1
  1. 1.Institute of Ophthalmology and Visual ScienceRutgers New Jersey Medical SchoolNewarkUSA

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