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Tuberculous Encephalitis

  • Jean Paul StahlEmail author
Chapter

Abstract

Mycobacterium tuberculosis is one of the most frequent aetiologies of infectious encephalitis, the most frequent remaining HSV. Its pathophysiology doesn’t differ from other non-pulmonary tuberculosis: it results from bacteremia and then locates in the brain. Microbiological diagnosis is not easy to obtain, as bacterial inoculum is low. PCR tests are not highly sensitive, so far. Remarkable feature in CSF biology is high protein level, significatively different from other aetiologies. Clinical presentation doesn’t differ from other encephalitis except the delay between the onset and diagnosis (10 days vs 2). The treatment drugs are the same than in other tuberculous localization, with a longer duration (12 months). Despite an adequate treatment, case fatality rate reaches 33% (9% in other encephalitis cases).

Keywords

Mycobacterium tuberculosis Encephalitis Mycobacterium tuberculosis PCR CSF adenosine deaminase Isoniazid Rifampicin Fluoroquinolone Pyrazinamide Ethambutol Brain MRI 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Infectious Diseases department. CHU and University Grenoble AlpesGrenobleFrance
  2. 2.ESGIB (European Study Group for the Infections of the Brain)DakarSenegal

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