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Urogenital Tuberculosis

  • Ekaterina Kulchavenya
  • Kurt G. Naber
  • Truls Erik Bjerklund Johansen
Chapter

Abstract

Urogenital tuberculosis (TB) is one of the most common forms among extrapulmonary TB. There are many controversies concerning epidemiology, definition, classification, treatment, and management of patients with urogenital TB. Urogenital TB includes kidney TB; urinary tract TB, which is a complication of kidney TB; and genital TB, both male and female. In this chapter detailed classification of urogenital TB is discussed. Modern approaches to the diagnostic work-up and chemotherapy of urogenital TB are described.

Keywords

Anti-TB drugs BCG therapy BCG-induced complications Bladder tuberculosis Chemotherapy Kidney tuberculosis Prostate tuberculosis Urogenital tuberculosis 

References

  1. 1.
    Porter MF III. Uro-genital tuberculosis in the male. Ann Surg. 1894;20(4):396–405.CrossRefGoogle Scholar
  2. 2.
    Wildbolz H. Ueber urogenical tuberkulose. Schweiz Med Wochenschr. 1937;67:1125.Google Scholar
  3. 3.
    Kulchavenya E. Urogenital tuberculosis: epidemiology, diagnosis, therapy. Cham/Heidelberg/New York/Dordrecht/London: Springer; 2014. p. 137. ISBN 978-2-319-04836-9.  https://doi.org/10.1007/978-3-319-04837-6.CrossRefGoogle Scholar
  4. 4.
    Kulchavenya E, Kim C-S. Male genital tuberculosis. In: Naber KG, Schaeffer AJ, Heyns CF, Matsumoto T, Shoskes DA, Bjerklund Johanses TE, editors. International Consultation on Urogenital Infections. International Consultation on Urological Diseases (ICUD). Arnhem: European Association of Urology (EAU); 2010. p. 892–903. ISBN: 978-90-79754-41-0. http://www.icud.info/urogenitalinfections.html.Google Scholar
  5. 5.
    Kulchavenya E, Kim CS, Bulanova O, Zhukova I. Male genital tuberculosis: epidemiology and diagnostic. World J Urol. 2012;30(1):15–21. Epub 2011 May21. ReviewCrossRefGoogle Scholar
  6. 6.
    Kamyshan IS. Guideline on urogenital tuberculosis. Kiev: Zdorov’e. 2003:363–424.Google Scholar
  7. 7.
    Narayana AS, Kelly DG, Duff FA. Tuberculosis of the penis. Br J Urol. 1976;48(4):274.CrossRefGoogle Scholar
  8. 8.
    Sharma VK, Sethy PK, Dogra PN, et al. Primary tuberculosis of glans penis after intravesical Bacillus Calmette Guerin immunotherapy. Indian J Dermatol Venereol Leprol. 2011;77(1):47–50.CrossRefGoogle Scholar
  9. 9.
    Lewis KE, Lucas MG, Smith R, Harrison NK. Urogenital infection by Mycobacterium bovis relapsing after 50 years. J Infect. 2003;46(4):246–8.CrossRefGoogle Scholar
  10. 10.
    de la Rua-Domenech R. Human Mycobacterium bovis infection in the United Kingdom: Incidence, risks, control measures and review of the zoonotic aspects of bovine tuberculosis. Tuberculosis (Edinb). 2006;86(2):77–109. Epub 2005 Oct 28.CrossRefGoogle Scholar
  11. 11.
    de Kantor IN, Lobue PA, Thoen CO. Human tuberculosis caused by Mycobacterium bovis in the United States, Latin America and the Caribbean. Int J Tuberc Lung Dis. 2010;14(11):1369–73.PubMedGoogle Scholar
  12. 12.
    Bhat S, Srinivasa Y, Paul F. Asymptomatic renal BCG granulomatosis: an unusual complication of intravesical BCG therapy for carcinoma urinary bladder. Indian J Urol. 2015;31(3):259–61.  https://doi.org/10.4103/0970-1591.156921.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Al-Qaoud T, Brimo F, Aprikian AG, Andonian S. BCG-related renal granulomas managed conservatively: A case series. Can Urol Assoc J. 2015;9(3–4):E200–3.  https://doi.org/10.5489/cuaj.2664.CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Pommier JD, Ben Lasfar N, Van Grunderbeeck N, et al. Complications following intravesical bacillus Calmette-Guerin treatment for bladder cancer: a case series of 22 patients. Infect Dis (Lond). 2015;47(10):729–35.  https://doi.org/10.3109/23744235.2015.1055794. Epub 2015 Jun 16.CrossRefGoogle Scholar
  15. 15.
    Pérez-Jacoiste Asín MA, Fernández-Ruiz M, López-Medrano F, et al. Bacillus Calmette-Guérin (BCG) infection following intravesical BCG administration as adjunctive therapy for bladder cancer: incidence, risk factors, and outcome in a single-institution series and review of the literature. Medicine (Baltimore). 2014;93(17):236–54.CrossRefGoogle Scholar
  16. 16.
    Miyake H, Fujisawa M. Tuberculosis in urogenital organs. Nihon Rinsho. 2011; Aug;69(8):1417–21.PubMedGoogle Scholar
  17. 17.
    Carrillo-Esper R, Moreno-Castañeda L, Hernández-Cruz AE, Aguilar-Zapata D. A renal tuberculosis. Cir Cir. 2010;78(5):442–7.PubMedGoogle Scholar
  18. 18.
    Bennani S, Hafiani M, Debbagh A, el Mrini M, Benjelloun S. Urogenital tuberculosis. Diagnostic aspects. J Urol. 1995;101(4):187–90.Google Scholar
  19. 19.
    Chiang LW, Jacobsen AS, Ong CL, Huang WS. Persistent sterile pyuria in children? Don't forget tuberculosis! Singap Med J. 2010;51(3):48–50.Google Scholar
  20. 20.
    Hoang NPC, Nhan LVH, Le Chuyen V. Genitourinary tuberculosis: diagnosis and treatment. Urology. 2009;(Supplement 4A):S241.Google Scholar
  21. 21.
    Hemal AK, Gupta NP, Rajeev TP, Kumar R, Dar L, Seth P. Polymerase chain reaction in clinically suspected genitourinary tuberculosis: comparison with intravenous urography, bladder biopsy, and urine acid fast bacilli culture. Urology. 2000;56(4):570–4.CrossRefGoogle Scholar
  22. 22.
    Kulchavenya EV, Brizhatyuk EV, Baranchukova AA, Cherednichenko AG, Klimova IP. Diagnostic Algorithm for prostate tuberculosis. Tuberk I bolezn legk. 2014;5:10–5.Google Scholar
  23. 23.
    Stasinou T, Bourdoumis A, Owegie P, Kachrilas S, Buchholz N, Masood J. Calcification of the vas deferens and seminal vesicles: a review. Can J Urol. 2015;22(1):7594–8.PubMedGoogle Scholar
  24. 24.
    Turkvatan A, Kelahmet E, Yazgan C, Olcer T. Sonographic findings in tuberculous epididymo-orchitis. J Clin Ultrasound. 2004;32(6):302–5.CrossRefGoogle Scholar
  25. 25.
    Wang LJ, Wong YC, Chen CJ, Lim KE. CT features of genitourinary tuberculosis. J Comput Assist Tomogr. 1997;21(2):254–8.CrossRefGoogle Scholar
  26. 26.
    Wang JH, Sheu MH, Lee RC. Tuberculosis of the prostate: MR appearance. J Comput Assist Tomogr. 1997;21(4):639–40.CrossRefGoogle Scholar
  27. 27.
    British Thoracic Society. Guidelines for the prevention and management of Mycobacterium tuberculosis infection and disease in adult patients with chronic kidney disease BTS Guideline Group on behalf of The British Thoracic Society Standards of Care Committee and Joint Tuberculosis Committee. Thorax. 2010;65:559–70.  https://doi.org/10.1136/thx.2009.133173.CrossRefGoogle Scholar
  28. 28.
    O’Donnell R. Drugs in renal failure. Antituberculous drugs. South West Medicines Information. NHS Ref: dosage adjustment of anti tuberculosis medication in patients with Renal Failure Department of Internal Medicine, PMHC.Google Scholar
  29. 29.
    Sharma JB, Singh N, Dharmendra S, Singh UB, P V, Kumar S, Roy KK, Hari S, Iyer V, Sharma SK. Six months versus nine months anti-tuberculous therapy for female genital tuberculosis: a randomized controlled trial. Eur J Obstet Gynecol Reprod Biol. 2016;203:264–73.CrossRefGoogle Scholar
  30. 30.
    Chang CH, Chen YF, Wu VC, Shu CC, Lee CH, Wang JY, Lee LN, Yu CJ. Acute kidney injury due to anti-tuberculosis drugs: a five-year experience in an aging population. BMC Infect Dis. 2014;14:23.CrossRefGoogle Scholar
  31. 31.
    WHO Guidelines for the treatment of drug-susceptible tuberculosis and patient care. 2017 update. WHO/HTM/TB/2017.05 http://apps.who.int/iris/bitstream/10665/255052/1/9789241550000-eng.pdf?ua=1. Accessed 30 Nov 2017.
  32. 32.
    Kulchavenya E. Current therapy and surgery for urogenital tuberculosis: Springer International Publishing Switzerland, 2016; ISBN 978-3-319-28288-6; ISBN 978-3-319-28290-9 (eBook);  https://doi.org/10.1007/978-3319-28290-9: 97 pages.
  33. 33.
    Singla R, Sharma SK, Mohan A, Makharia G, Sreenivas V, Jha B, et al. Evaluation of risk factors for antituberculosis treatment induced hepatotoxicity. Indian J Med Res. 2010;132:81–6.PubMedGoogle Scholar
  34. 34.
    Chung-Delgado K, Revilla-Montag A, Guillen-Bravo S, Velez-Segovia E, Soria-Montoya A, Nuñez-Garbin A, et al. Factors associated with anti-tuberculosis medication adverse effects: a case-control study in Lima, Peru. PLoS One. 2011;6(11):e27610.  https://doi.org/10.1371/journal.pone.0027610. Epub 2011 Nov 16.CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Swaminathan A, du Cros P, Seddon JA, Mirgayosieva S, Asladdin R, Dusmatova Z. Peripheral neuropathy in a diabetic child treated with linezolid for multidrug-resistant tuberculosis: a case report and review of the literature. BMC Infect Dis. 2017;17(1):417.  https://doi.org/10.1186/s12879-017-2499-1.CrossRefPubMedPubMedCentralGoogle Scholar
  36. 36.
    Hassan WA, Darwish AM. Impact of pulmonary tuberculosis on menstrual pattern and fertility. Clin Respir J. 2010;4(3):157–61.  https://doi.org/10.1111/j.1752-699X.2009.00166.x.CrossRefPubMedGoogle Scholar
  37. 37.
    Hassan WA, Darwish AM. Impact of pulmonary tuberculosis on menstrual pattern and fertility. Chest. 2009;136(1):326.  https://doi.org/10.1378/chest.09-0594.CrossRefPubMedGoogle Scholar
  38. 38.
    Kulchavenya EV, Osadchii AV. The role of pathogenetic therapy in preserving ejaculate fertility in patients with tuberculosis of prostate. Urologiia. 2016;3:14–8.Google Scholar
  39. 39.
    Kulchavenya E, Medvedev S. Therapy for pulmonary tuberculosis as a reason for ejaculatory disorders. J Sex Med. 2011;8(suppl 5):384–405 - HP-23.Google Scholar
  40. 40.
    Kulchavenya E, Scherban M, Brizhatyuk E, Osadchiy A. Sexual dysfunction in male patients with pulmonary tuberculosis. J Microbiol Infect Dis. 2012;2(3):124–6.  https://doi.org/10.5799/ahinjs.02.2012.03.0057.CrossRefGoogle Scholar
  41. 41.
    Kulchavenya E, Zhukova I, Kholtobin D. Spectrum of urogenital tuberculosis. J Infect Chemother. 2013;19(5):880–3.CrossRefGoogle Scholar
  42. 42.
    Kholtobin D, Kulchavenya EV. Surgery for bladder tuberculosis. Palmarium Academium Publishing (Germany); 2013. p. 76.Google Scholar
  43. 43.
    Singh V, Sinha RJ, Sankhwar SN, Sinha SM. Reconstructive surgery for tuberculous contracted bladder: experience of a center in northern India. Int Urol Nephrol. 2011; Jun;43(2):423–30.CrossRefGoogle Scholar
  44. 44.
    Suárez-Grau JM, Bellido-Luque JA, Pastrana-Mejía A, et al. Laparoscopic surgery of an enterovesical fistula of tuberculous origin (terminal ileum and sigmoid colon). Rev Esp Enferm Dig. 2012;104(7):391–2.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ekaterina Kulchavenya
    • 1
    • 2
  • Kurt G. Naber
    • 3
  • Truls Erik Bjerklund Johansen
    • 4
    • 5
  1. 1.Novosibirsk Research TB InstituteNovosibirskRussian Federation
  2. 2.Novosibirsk State Medical UniversityNovosibirskRussian Federation
  3. 3.Department of UrologyTechnical University of MunichMunichGermany
  4. 4.Urology DepartmentOslo University Hospital and Institute of Clinical Medicine, University of OsloOsloNorway
  5. 5.Institute of Clinical Medicine, Aarhus UniversityAarhusDenmark

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