Biomedical Applications of Hydroxyapatite Nanocomposites

  • Mariappan RajanEmail author
  • Murugan Sumathra
Part of the Lecture Notes in Bioengineering book series (LNBE)


This book chapter details the recent and very recent work on biomedical applications of hydroxyapatite nanocomposites. Single component of hydroxyapatite has not fulfilled the all obligation of biomedical process. The hydroxyapatite-reinforced polymer nanocomposites imitate the inhabitant tissue microenvironment due to their porous and molecular structure. An emerging approach has been involved as the reinforced polymeric compounds and to include multiple functionalities. Wide ranges of nanocomposites such as carbon-based, polymeric, ceramic, and metallic nanomaterial can be integrated within the hydrogel network to obtain nanocomposites with superior properties and tailored functionality. Hydroxyapatite nanocomposites can be engineered to possess superior physical, chemical, electrical, and biological properties. Mainly this book chapter deals with the hydroxyapatite composites applied for various application specifically tissue engineering, drug delivery, gene carriers and photodynamic therapy are discussed.


Biomedical Hydroxyapatite Tissue regeneration 





Alkaline phosphate activity






Bone marrow-derived mesenchymal stem cells


Bone sialoprotein


Bone Morphogenic Protein


Beta-Tri-calcium phosphate




Carboxy Methyl Cellulose


Chitosan microspheres


Carbon Nanotube




Nanocrystalline Carbonated Hydroxyapatite






Dexamethasone–bovine serum albumin


Extracellular Matrix


Gellan gum








High Perspective Proportion Vessel


Mesoporus Bioactive glass


Mesenchymal stem cells


Human mesenchymal stem cells


osteoblast cell line separated from mus musculus calvaria






Polyethylene Glycol


Polyethylen imine




Poly(lactic-co-glycolic acid)


Poly-l-Lactic acid


Poly (ethylene adipate-co-d,l-lactic acid)


Polyvinyl alcohol


messenger Ribonucleic acid


Sodium Alginate




Stimulated Body Fluid


Tetrakis Hydroxy Phenyl Porphrin


X-ray diffraction


X-ray photoelectron spectroscopy


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of ChemistryMadurai Kamaraj UniversityMaduraiIndia

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