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Biomedical Applications of Hydroxyapatite Nanocomposites

  • Mariappan RajanEmail author
  • Murugan Sumathra
Chapter
Part of the Lecture Notes in Bioengineering book series (LNBE)

Abstract

This book chapter details the recent and very recent work on biomedical applications of hydroxyapatite nanocomposites. Single component of hydroxyapatite has not fulfilled the all obligation of biomedical process. The hydroxyapatite-reinforced polymer nanocomposites imitate the inhabitant tissue microenvironment due to their porous and molecular structure. An emerging approach has been involved as the reinforced polymeric compounds and to include multiple functionalities. Wide ranges of nanocomposites such as carbon-based, polymeric, ceramic, and metallic nanomaterial can be integrated within the hydrogel network to obtain nanocomposites with superior properties and tailored functionality. Hydroxyapatite nanocomposites can be engineered to possess superior physical, chemical, electrical, and biological properties. Mainly this book chapter deals with the hydroxyapatite composites applied for various application specifically tissue engineering, drug delivery, gene carriers and photodynamic therapy are discussed.

Keywords

Biomedical Hydroxyapatite Tissue regeneration 

Abbreviations

ALG

Alginate

ALP

Alkaline phosphate activity

ARG

Arginine

AMX

Amoxillin-clavulanate

BMSCs

Bone marrow-derived mesenchymal stem cells

BSP

Bone sialoprotein

BMP-2

Bone Morphogenic Protein

β-TCP

Beta-Tri-calcium phosphate

CS

Chitosan

CMC

Carboxy Methyl Cellulose

CMPs

Chitosan microspheres

CNT

Carbon Nanotube

5-FCil

5-Fluorouracil

nCHA

Nanocrystalline Carbonated Hydroxyapatite

COLL

Collagen

Dox

Doxorubicin

DEX/BSA

Dexamethasone–bovine serum albumin

ECM

Extracellular Matrix

GG

Gellan gum

GM

Gentamicin

HA

Hydroxyapatite

n-HA

Nano-Hydroxyapatite

HARV

High Perspective Proportion Vessel

MBG/HA

Mesoporus Bioactive glass

MSCs

Mesenchymal stem cells

hMSCs

Human mesenchymal stem cells

MC3T3-E1

osteoblast cell line separated from mus musculus calvaria

MMT

Montmorillonite

PCL

Polycaprolactone

PEG

Polyethylene Glycol

PEI

Polyethylen imine

PHB

Poly(hydroxybutyrate)

PLGA

Poly(lactic-co-glycolic acid)

PLLA

Poly-l-Lactic acid

PLEA

Poly (ethylene adipate-co-d,l-lactic acid)

PVA

Polyvinyl alcohol

mRNA

messenger Ribonucleic acid

SA

Sodium Alginate

SF

Silk

SBF

Stimulated Body Fluid

M-THPP

Tetrakis Hydroxy Phenyl Porphrin

XRD

X-ray diffraction

XPS

X-ray photoelectron spectroscopy

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of ChemistryMadurai Kamaraj UniversityMaduraiIndia

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