Nutraceuticals in Cattle Health and Diseases

  • Begüm Yurdakok-Dikmen
  • Ayhan Filazi


As a result of growing consumer demand for “clean, green, and ethical” products related to public awareness of environmental and health risks of veterinary medicinal products—and the increase in antimicrobial resistance, leading to loss of effectiveness—beef and dairy producers are striving to find effective alternatives. Nutraceuticals provide a valuable tool for prevention and control of diseases in ruminants through their antioxidant, anti-inflammatory, and antimicrobial effects. Nutraceuticals with beneficial effects on the rumen microbiota contribute to increases in productivity and profitability, since the rumen plays an important role in the immune system and nutrition. The beneficial effects are not restricted to cattle health but also impact the environment as a result of their positive impacts on methane emissions. These compounds also have the potential to increase the “healthy fats” in the final products, which are favored for human health. Therefore, nutraceuticals (including probiotics, prebiotics, and synbiotics), dietary lipids, proteins and peptides (including antimicrobial peptides), algae (macroalgae and microalgae), and phytonutraceuticals (tannins, saponins, and essential oils) are valuable tools in cattle health and disease. Meanwhile, many factors affect the efficacy of nutraceuticals, including the source, production technique, and concentration of the compound, along with the physical condition, diet, species, and rumen pH of the animal. To achieve the maximum benefits of nutraceuticals, more studies should be performed to assess their efficacy and toxicity in different ruminant species with different physiological conditions.


Cattle Nutraceuticals Probiotics Prebiotics Synbiotics Dietary lipids proteins and peptides Algae Phytonutraceuticals 


  1. Abeyrathne EDNS, Lee HY, Ahn DU (2013) Egg white proteins and their potential use in food processing or as nutraceutical and pharmaceutical agents—a review. Poult Sci 92(12):3292–3299PubMedGoogle Scholar
  2. Acuff GR (2005) Chemical decontamination strategies for meat. In: Sofos NJ (ed) Improving the safety of fresh meat. Woodhead Publishing, Cambridge, pp 350–363Google Scholar
  3. Addisu S, Assefa A (2016) Role of plant containing saponin on livestock production; a review. Adv Biol Res 10(5):309–314Google Scholar
  4. Ageitos JM, Sánchez-Pérez A, Calo-Mata P et al (2017) Antimicrobial peptides (AMPs): ancient compounds that represent novel weapons in the fight against bacteria. Biochem Pharmacol 133:117–138PubMedGoogle Scholar
  5. Ahmad A, Hayat I, Arif S et al (2014) Mechanisms involved in the therapeutic effects of soybean (Glycine max). Int J Food Prop 17(6):1332–1354Google Scholar
  6. Allen VG, Pond KR, Saker KE et al (2001) Tasco-forage: III influence of a seaweed extract on performance, monocyte immune cell response, and carcass characteristics in feedlot-finished steers. J Anim Sci 79(4):1032–1040PubMedGoogle Scholar
  7. Al-Sobayil KA, Zeitoun MM, Khalil MH et al (2008) Effect of oral administration of a functional synbiotic syrup on libido, semen characteristics, serum testosterone and liver and kidney function of goat’s bucks. Asian J Biol Sci 1(1):11–18Google Scholar
  8. Alwathnani H, Perveen K (2017) Antibacterial activity and morphological changes in human pathogenic bacteria caused by Chlorella vulgaris extracts. Biomed Res 28(4):1610–1614Google Scholar
  9. Auclair E (2001) Yeast as an example of the mode of action of probiotics in monogastric and ruminant species. In: Brufau J (ed) Feed manufacturing in the Mediterranean region improving safety: from feed to food. CIHEAM, Zaragoza, pp 45–53Google Scholar
  10. Ballester-Costa C, Sendra E, Fernández-López J et al (2017) Assessment of antioxidant and antibacterial properties on meat homogenates of essential oils obtained from four thymus species achieved from organic growth. Foods 6(8):59PubMedCentralGoogle Scholar
  11. Bouga M, Combet E (2015) Emergence of seaweed and seaweed-containing foods in the UK: focus on labeling, iodine content, toxicity and nutrition. Foods 4(2):240–253. CrossRefPubMedPubMedCentralGoogle Scholar
  12. Bragaglio A, Braghieri A, Napolitano F et al (2015) Omega-3 supplementation, milk quality and cow immune-competence. Ital J Agron 10(1):9–14Google Scholar
  13. Broderick GA, Wallace RJ (1988) Effects of dietary nitrogen source on concentrations of ammonia, free amino acids and fluorescamine-reactive peptides in the sheep rumen. J Anim Sci 66:2233–2238Google Scholar
  14. Brunet S, Hoste H (2006) Monomers of condensed tannins affect the larval exsheathment of parasitic nematodes of ruminants. J Agric Food Chem 54(20):7481–7487PubMedGoogle Scholar
  15. Callaway TR, Edrington TS, Harvey RB et al (2012) Prebiotics in food animals, a potential to reduce foodborne pathogens and disease. Roman Biotechnol Let 17(6):7808–7816Google Scholar
  16. Carroll SM, DePeters EJ, Rosenberg M (2006) Efficacy of a novel whey protein gel complex to increase the unsaturated fatty acid composition of bovine milk fat. J Dairy Sci 89(2):640–650PubMedGoogle Scholar
  17. Chapman CMC, Gibson GR, Rowland I (2011) Health benefits of probiotics: are mixtures more effective than single strains? Eur J Nutr 50(1):1–17PubMedGoogle Scholar
  18. Chaucheyras-Durand F, Durand H (2010) Probiotics in animal nutrition and health. Benef Microbes 1(1):3–9PubMedGoogle Scholar
  19. Cheema U, Younas M, Sultan J et al (2011) Antimicrobial peptides: an alternative of antibiotics in ruminants. Adv Agric Biotechnol 2:15–21Google Scholar
  20. Chiquette J (2009) Evaluation of the protective effect of probiotics fed to dairy cows during a subacute ruminal acidosis challenge. Anim Feed Sci Technol 153(3–4):278–291Google Scholar
  21. Cobellis G, Trabalza-Marinucci M, Yu Z (2016) Critical evaluation of essential oils as rumen modifiers in ruminant nutrition: a review. Sci Total Environ 545–546:556–568PubMedGoogle Scholar
  22. Colmenero JJO, Broderick GA (2006) Effect of amount and ruminal degradability of soybean meal protein on performance of lactating dairy cows. J Dairy Sci 89(5):1635–1643PubMedGoogle Scholar
  23. Das L, Bhaumik E, Raychaudhuri U et al (2012) Role of nutraceuticals in human health. J Food Sci Technol 49(2):173–183PubMedGoogle Scholar
  24. de Mejia EG, Dia VP (2010) The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells. Cancer Metastasis Rev 29(3):511–528PubMedGoogle Scholar
  25. Dormán G, Flachner B, Hajdú I et al (2016) Target identification and polypharmacology of nutraceuticals. In: Gupta RC (e) (ed) Nutraceuticals: efficacy, safety and toxicity. Academic, Amsterdam, pp 263–286Google Scholar
  26. Drackley JK (2004) Overview of fat digestion and metabolism in dairy cows. Illinois Livestock Trail, University of Illinois.
  27. El-Shewy AA (2016) Whey as a feed ingredient for lactating cattle. Sci Int 4(3):80–85Google Scholar
  28. Evans FD, Critchley AT (2014) Seaweeds for animal production use. J Appl Phycol 26(2):891–899Google Scholar
  29. FitzGerald RJ (1998) Potential uses of caseinophosphopeptides. Int Dairy J 8(5–6):451–457Google Scholar
  30. Fleige S, Preißinger W, Meyer HHD et al (2007) Effect of lactulose on growth performance and intestinal morphology of pre-ruminant calves using a milk replacer containing Enterococcus faecium. Animal 1(03):367–373PubMedGoogle Scholar
  31. Froehlich KA, Abdelsalam KW, Chase C et al (2017) Evaluation of essential oils and prebiotics for newborn dairy calves. J Anim Sci 95(8):3772–3782PubMedGoogle Scholar
  32. Gaggìa F, Mattarelli P, Biavati B (2010) Probiotics and prebiotics in animal feeding for safe food production. Int J Food Microbiol 141:S15–S28PubMedGoogle Scholar
  33. Ghasemi Y, Moradian A, Mohagheghzadeh A et al (2007) Antifungal and antibacterial activity of the microalgae collected from paddy fields of Iran: characterization of antimicrobial activity of Chroococcus dispersus. J Biol Sci 7(6):904–910Google Scholar
  34. Guyader J, Eugène M, Doreau M et al (2017) Tea saponin reduced methanogenesis in vitro but increased methane yield in lactating dairy cows. J Dairy Sci 100(3):1845–1855PubMedGoogle Scholar
  35. Hamasalim HJ (2016) Synbiotic as feed additives relating to animal health and performance. Adv Microbiol 6:288–302Google Scholar
  36. Hatoum R, Labrie S, Fliss I (2012) Antimicrobial and probiotic properties of yeasts: from fundamental to novel applications. Front Microbiol 19(3):421Google Scholar
  37. Hayashi T, Hayashi K, Maeda M et al (1996) Calcium spirulan, an inhibitor of enveloped virus replication, from a blue-green alga Spirulina platensis. J Nat Prod 59(1):83–87PubMedGoogle Scholar
  38. Hong ZS, Kim EJ, Jin YC et al (2015) Effects of supplementing brown seaweed by-products in the diet of Holstein cows during transition on ruminal fermentation, growth performance and endocrine responses. Asian-Australas J Anim Sci 28(9):1296–1302PubMedPubMedCentralGoogle Scholar
  39. Ingvartsen KL, Moyes K (2013) Nutrition, immune function and health of dairy cattle. Animal 7(S1):112–122PubMedGoogle Scholar
  40. Jayanegara A, Wina E, Takahashi J (2014) Meta-analysis on methane mitigating properties of saponin-rich sources in the rumen: influence of addition levels and plant sources. Asian-Australas J Anim Sci 27(10):1426–1435PubMedPubMedCentralGoogle Scholar
  41. Jenssen H, Hancock R (2009) Antimicrobial properties of lactoferrin. Biochimie 91(1):19–29PubMedGoogle Scholar
  42. Jerónimo E, Pinheiro C, Lamy E et al (2016) Tannins in ruminant nutrition—impact on animal performance and quality of edible products. In: Combs CA (ed) Tannins: biochemistry, food sources and nutritional properties. Nova Science, New York, pp 121–168Google Scholar
  43. Jinturkar AS, Gujar BV, Chauhan DS, et al (2009) Effect of feeding probiotics on the growth performance and feed conversion efficiency in goat. Indian Journal of Animal Research 43(1): 49–52Google Scholar
  44. Kadegowda AKG, Yu L (2016) Effects of dietary lipid intake on diabetes functional dietary lipids. In: Sanders TAB (ed.) Functional dietary lipids food formulation, consumer issues and innovation for health (pp 151–176) Amsterdam WoodheadGoogle Scholar
  45. Kelly GS (2001) Conjugated linoleic acid: a review. Alt Med Rev 6(4):367–382Google Scholar
  46. Kieckens E, Rybarczyk J, Cox E et al (2018) Antibacterial and immunomodulatory activities of bovine lactoferrin against Escherichia coli O157:H7 infections in cattle. Biometals 31(3):321–330PubMedGoogle Scholar
  47. Kirk DD, Rempel R, Pinkhasov J et al (2004) Application of Quillaja saponaria extracts as oral adjuvants for plant-made vaccines. Expert Opin Biol Ther 4(6):947–958PubMedGoogle Scholar
  48. Kumari S, Pundhir S, Priya P, et al (2014) EssOilDB: a database of essential oils reflecting terpene composition and variability in the plant kingdom. Database 2014:bau120Google Scholar
  49. Maamouri O, Selmi H, M’hamdi N (2014) Effects of yeast (Saccharomyces cerevisiae) feed supplement on milk production and its composition in Tunisian Holstein Friesian cows. Sci Agric Bohem 45(3):170–174Google Scholar
  50. Madeira MS, Cardoso C, Lopes PA et al (2017) Microalgae as feed ingredients for livestock production and meat quality: a review. Livest Sci 205:111–121Google Scholar
  51. Maia MRG, Fonseca AJM, Oliveira HM et al (2016) The potential role of seaweeds in the natural manipulation of rumen fermentation and methane production. Sci Rep 6(1):323–321Google Scholar
  52. Makkar HPS, Tran G, Heuzé V et al (2016) Seaweeds for livestock diets: a review. Anim Feed Sci Technol 212:1–17Google Scholar
  53. Malkoski M, Dashper SG, O’Brien-Simpson NM et al (2001) Kappacin, a novel antibacterial peptide from bovine milk. Antimicrob Agents Chemother 45(8):2309–2315PubMedPubMedCentralGoogle Scholar
  54. Mandel S, Packer L, Youdim MBH et al (2005) Proceedings from the “Third International Conference on Mechanism of Action of Nutraceuticals”. J Nutr Biochem 16(9):513–520PubMedGoogle Scholar
  55. McGrath J, Duval SM, Tamassia LFM et al (2018) Nutritional strategies in ruminants: a lifetime approach. Res Vet Sci 116:28–39PubMedGoogle Scholar
  56. Mine Y, Shahidi F (2005) Nutraceutical proteins and peptides in health and disease: an overview. In: Mine Y, Shahidi F (e) (eds) Nutraceutical proteins and peptides in health and disease. CRC, Boca Raton, pp 3–9Google Scholar
  57. Mir PS, McAllister TA, Scott S et al (2004) Conjugated linoleic acid–enriched beef production. Am J Clin Nutr 79(6S):1207S–1211SPubMedGoogle Scholar
  58. Mirzaei-Aghsaghali A, Maheri-Sis N (2011) Importance of “physically effective fibre” in ruminant nutrition: a review. Ann Biol Res 2(3):262–270Google Scholar
  59. Moarrab A, Ghoorchi T, Ramezanpour S et al (2016) Effect of synbiotic on performance, intestinal morphology, fecal microbial population and blood metabolites of suckling lambs. Iran J Appl Anim Sci 6(3):621–628Google Scholar
  60. Morales R, Ungerfeld EM (2015) Use of tannins to improve fatty acids profile of meat and milk quality in ruminants: a review. Chil J Agric Res 75(2):239–248Google Scholar
  61. Moreira LM, Leonel FP, Vieira RAM et al (2013) A new approach about the digestion of fibers by ruminants. R Brasil Saúde Prod Anim 14(2):382–395Google Scholar
  62. Mueller-Harvey I (2006) Unravelling the conundrum of tannins in animal nutrition and health. J Sci Food Agric 86(13):2010–2037Google Scholar
  63. Naumann HD, Tedeschi LO, Zeller WE et al (2017) The role of condensed tannins in ruminant animal production: advances, limitations and future directions. R Bras Zootec 46(12):929–949Google Scholar
  64. Nicoletti M (2016) Microalgae nutraceuticals. Foods 5(3):54PubMedCentralGoogle Scholar
  65. Oyama LB, Girdwood SE, Cookson AR et al (2017) The rumen microbiome: an underexplored resource for novel antimicrobial discovery. NPJ Biofilms Microbiomes 3(1):33PubMedPubMedCentralGoogle Scholar
  66. Palmquist DL, Conrad HR (1978) High fat rations for dairy cows effects on feed intake, milk and fat production, and plasma metabolites. J Dairy Sci 61(7):890–901Google Scholar
  67. Palou A, Bonet ML (2007) Controlling lipogenesis and thermogenesis and the use of ergogenic aids for weight control. In: Henry CJK (ed) Novel food ingredients for weight control. Woodhead Publishing, Cambridge, pp 58–103Google Scholar
  68. Patra AK (2011) Effects of essential oils on rumen fermentation, microbial ecology and ruminant production. Asian J Anim Vet Adv 6(5):416–428Google Scholar
  69. Patra AK, Saxena J (2009) The effect and mode of action of saponins on the microbial populations and fermentation in the rumen and ruminant production. Nutr Res Rev 22(02):204–219PubMedGoogle Scholar
  70. Piñeiro-Vázquez AT, Canul-Solís JR, Alayón-Gamboa JA et al (2015) Potential of condensed tannins for the reduction of emissions of enteric methane and their effect on ruminant productivity. Arch Med Vet 47:263–272Google Scholar
  71. Pratt R, Daniels TC, Eiler JJ et al (1944) Chlorellin, an antibacterial substance from Chlorella. Science 99(1944):351–352PubMedGoogle Scholar
  72. Radivojević M, Grubić G, Šamanc H et al (2011) Heat treated soybeans in the nutrition of high producing dairy cows. Afr J Biotechnol 10(19):3929–3937Google Scholar
  73. Radzikowski D (2017) Effect of probiotics, prebiotics and synbiotics on the productivity and health of dairy cows and calves. World Sci News 78:193–198Google Scholar
  74. Retta KS (2016) Role of probiotics in rumen fermentation and animal performance: a review. Int J Livest Prod 7(5):24–32Google Scholar
  75. Roberfroid M, Gibson GR, Hoyles L et al (2010) Prebiotic effects: metabolic and health benefits. Br J Nutr 104(S2):S1–S63PubMedGoogle Scholar
  76. Roodposhti P, Dabiri N (2012) Effects of probiotic and prebiotic on average daily gain, fecal shedding of Escherichia coli, and immune system status in newborn female calves. Asian-Australas J Anim Sci 25(9):1255–1261PubMedPubMedCentralGoogle Scholar
  77. Saker KE, Fike JH, Veit H et al (2004) Brown seaweed (Tasco™) treated conserved forage enhances antioxidant status and immune function in heat-stressed wether lambs. J Anim Physiol Anim Nutr 88(3–4):122–130Google Scholar
  78. Saleem AM, Zanouny AI, Singer AM (2017) Growth performance, nutrients digestibility, and blood metabolites of lambs fed diets supplemented with probiotics during pre- and post-weaning period. Asian-Australas J Anim Sci 30(4):523–530PubMedGoogle Scholar
  79. Salem MB, Fraj M (2007) The effects of feeding liquid acid whey in the diet of lactating dairy cows on milk production and composition. J Cell Anim Biol 1(1):7–10Google Scholar
  80. Savoini G, Agazzi A, Invernizzi G et al (2010) Polyunsaturated fatty acids and choline in dairy goats nutrition: production and health benefits. Small Rumin Res 88(2–3):135–144Google Scholar
  81. Schingoethe DJ (1976) Whey utilization in animal feeding: a summary and evaluation. J Dairy Sci 59(3):556–570Google Scholar
  82. Shimazaki K, Kawano N, Yoo YC (1991) Comparison of bovine, sheep and goat milk lactoferrins in their electrophoretic behavior, conformation, immunochemical properties and lectin reactivity. Comp Biochem Physiol B 98(2–3):417–422PubMedGoogle Scholar
  83. Škrovánková S (2011) Seaweed vitamins as nutraceuticals. Adv Food Nutr Res 64:357–369PubMedGoogle Scholar
  84. Spickler AR, Roth JA (2003) Adjuvants in veterinary vaccines: modes of action and adverse effects. J Vet Int Med 17:273–281Google Scholar
  85. Stamey JA, Shepherd DM, de Veth MJ et al (2012) Use of algae or algal oil rich in n-3 fatty acids as a feed supplement for dairy cattle. J Dairy Sci 95(9):5269–5275PubMedGoogle Scholar
  86. Suarez C, Guevara CA (2018) Probiotic use of yeast Saccharomyces cerevisiae in animal feed. Res J Zool 1:1Google Scholar
  87. Sun DS, Jin X, Shi B et al (2017) Effects of Yucca schidigera on gas mitigation in livestock production: a review. Braz Arch Biol Technol 60(0):e17160359Google Scholar
  88. Tackett VL, Bertrand JA, Jenkins TC et al (1996) Interaction of dietary fat and acid detergent fiber diets of lactating dairy cows. J Dairy Sci 79(2):270–275PubMedGoogle Scholar
  89. Tiven NC, Siwa IP, Joris L (2016) Effects of Citrus hystryx as fat protector on unsaturated fatty acids, cholesterol and chemical composition of lamb meat. J Indones Trop Anim Agric (1):45–49Google Scholar
  90. Tsai YC, Castillo LS, Hardison WA et al (1967) Effect of dietary fiber level on lactating dairy cows in the humid tropics. J Dairy Sci 50(7):1126–1129Google Scholar
  91. Tsuda T, Sasaki Y, Kawashima R (1991) Physiological aspects of digestion and metabolism in ruminants. In: Tsuda T, Sasaki Y, Kawashima R (eds) Proceedings of the Seventh International Symposium on Ruminant Physiology, San Diego AcademicGoogle Scholar
  92. Ure AL, Dhiman TR, Stern MD et al (2005) Treated extruded soybean meal as a source of fat and protein for dairy cows. Asian-Australas J Anim Sci 18(7):980–989Google Scholar
  93. Uyeno Y, Shigemori S, Shimosato T (2015) Effect of probiotics/prebiotics on cattle health and productivity microbes and environments. Microbes Environ 30(2):126–132PubMedPubMedCentralGoogle Scholar
  94. Vahmani P, Mapiye C, Prieto N et al (2015) The scope for manipulating the polyunsaturated fatty acid content of beef: a review. J Anim Sci Biotechnol 6(1):29PubMedPubMedCentralGoogle Scholar
  95. Vakili AR, Khorrami B, Mesgaran MD et al (2013) The effects of thyme and cinnamon essential oils on performance, rumen fermentation and blood metabolites in Holstein calves consuming high concentrate diet. Asian-Australas J Anim Sci 26(7):935–944PubMedPubMedCentralGoogle Scholar
  96. Van Tran L, Malla BA, Kumar S et al (2016) Polyunsaturated fatty acids in male ruminant reproduction—a review. Asian-Australas J Anim Sci 30(5):622–637PubMedPubMedCentralGoogle Scholar
  97. Vasta V, Luciano G (2011) The effects of dietary consumption of plants secondary compounds on small ruminants’ products quality. Small Rumin Res 101(1–3):150–159Google Scholar
  98. Vohra A, Syal P, Madan A (2016) Probiotic yeasts in livestock sector. Anim Feed Sci Technol 219:31–47Google Scholar
  99. Wallace RJ, Newbold CJ (1992) Probiotics for ruminants. In: Fuller R (ed) Probiotics. Springer, Dordrecht, pp 317–353Google Scholar
  100. Wang Y, Xu Z, Bach SJ et al (2008) Effects of phlorotannins from Ascophyllum nodosum (brown seaweed) on in vitro ruminal digestion of mixed forage or barley grain. Anim Feed Sci Technol 145(1–4):375–395Google Scholar
  101. Wang S, Zeng X, Yang Q et al (2016) Antimicrobial peptides as potential alternatives to antibiotics in food animal industry. Int J Mol Sci 17(5):603PubMedCentralGoogle Scholar
  102. Wereme D, Grongnet JF, Gelbcke D (2016) Using unmarketable egg powder as protein supplement in pre-ruminant lamb milk replacer. Direct Res J Agric Food Sci 4(9):271–279Google Scholar
  103. Westendarp H (2005) Saponins in nutrition of swine, poultry and ruminants. Dtsch Tierarztl Wochenschr 112(2):65–70PubMedGoogle Scholar
  104. Williams AR, Fryganas C, Ramsay A et al (2014) Direct anthelmintic effects of condensed tannins from diverse plant sources against Ascaris suum. PLoS One 9(5):e97053PubMedPubMedCentralGoogle Scholar
  105. Woodford JA, Jorgensen NA, Barrington GP (1986) Impact of dietary fiber and physical form on performance of lactating dairy cows. J Dairy Sci 69(4):1035–1047PubMedGoogle Scholar
  106. Xiao CW (2008) Health effects of soy protein and isoflavones in humans. J Nutr 138(6):1244S–1249SPubMedGoogle Scholar
  107. Xiao CW, L’Abbé MR, Gilani GS et al (2004) Dietary soy protein isolate and isoflavones modulate hepatic thyroid hormone receptors in rats. J Nutr 134(4):743–749PubMedGoogle Scholar
  108. Zebeli Q, Dijkstra J, Tafaj M et al (2008) Modeling the adequacy of dietary fiber in dairy cows based on the responses of ruminal pH and milk fat production to composition of the diet. J Dairy Sci 91(5):2046–2066PubMedGoogle Scholar
  109. Zhang H, Wang Z, Liu G et al (2011) Effect of dietary fat supplementation on milk components and blood parameters of early-lactating cows under heat stress. Slovak J Anim Sci 44(2):52–58Google Scholar

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Authors and Affiliations

  • Begüm Yurdakok-Dikmen
    • 1
  • Ayhan Filazi
    • 1
  1. 1.Department of Pharmacology and Toxicology, Faculty of Veterinary MedicineAnkara UniversityAnkaraTurkey

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