Fern to Pharma: Potential Neuroameliorative Properties of Pteridophytes

  • Girish Chandran
  • S. R. Smitha Grace
  • Jyoti Bala Chauhan


Neurodegenerative disorders (NDD) have major implications on the socioeconomic-civic status of the world communities. There are a number of drugs already available in the market and newer therapeutic strategies are being reported continuously. However, these drugs usually fail in their long-term efficacy and tend to enhance the pathophysiology of the NDD. However, the bioactives of herbal origin have proved their neuroameliorative efficacy through both targeted and peripheral effects along with no and limited side effects. Hence, there is a constant pursuit of neuroprotective bioactives from the plant sources. Ferns are the largest group of unexplored plants for their therapeutic uses in contrast to the angiosperms. Though a vast number of polyphenols and bioactives are being reported from ferns (pteridophytes) detailed studies addressing their biological properties are limited. This may be due to the limited availability in most parts of the world and lack of sociopolitical interests to save the traditional herbal drug library, which is usually carried forward from generation to generations by way of mere memory of a particular designated family or descendants in a locality. Hitherto, there are a few experimental reports about the beneficial effects of bioactives isolated from fern species. These properties range from in vitro antioxidant and anti-inflammatory in cell lines to in vivo neuroprotective properties among mice and Drosophila models. A recent review has enlisted various phytochemicals reported from different fern families. In this chapter we have made conscious efforts to review the recent literature on the bioactives from various pteridophytes with respect to their proven and possible neuroprotective properties.


Pteridophytes Neuroprotection Oxidative stress Parkinson’s disease Alzheimer’s disease 


Conflict of Interest

Authors declare that there is no conflict of interest.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Girish Chandran
    • 1
  • S. R. Smitha Grace
    • 1
  • Jyoti Bala Chauhan
    • 1
  1. 1.Biochemistry, Department of Lifesciences, Pooja Bhagavat Memorial Mahajana Education CentrePost Graduate Wing of SBRR Mahajana First Grade College, MetagalliMysuruIndia

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