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Anti-sickling Herbs

  • Shweta Jain
  • Ankur Vaidya
  • Kamal Shah
  • Durgesh Nandini Chauhan
  • Nagendra Singh Chauhan
Chapter

Abstract

Sickle cell disease (SCD) is known to be one of the diseases wrecking most parts of the globe with 89% of sickle patients worldwide in Africa, of which Nigeria alone constitutes 25%. It was first reported by Dr. James Herrick in 1910 and the subsequent characterisation was by Linus Pauling. SCD is a genetic blood disorder, characterised by modification in the shape of the red blood cell from a smooth, donut shape into a crescent or half-moon shape. The practice of traditional medicine using medicinal plants has a long history in the treatment of sickle cell disease. The role of nutrition and anti-sickling effects of various phytoconstituents in overcoming SCD has been reported, although information on the management of SCD is still scarce.

Keywords

Erythrocyte Haemoglobin Isolation Plant extract Sickle cell 

References

  1. Abreu PM, Noronha RG (1997) Volatile constituents of the rhizomes of Aframomum alboviolaceum (Ridley) K. Schum. from Guinea-Bissau. Flav Frag J 12:79–83CrossRefGoogle Scholar
  2. Abu AH, Uchendu CN (2011) Effect of aqueous ethanolic extract of Hymenocardia acida stem bark on oestrous cycle of albino rats. J Med Plants Res 5(8):1280–1283Google Scholar
  3. Adejumo E, Adelodun LK, Oladimeji PR, Lateef SK (2010) In vitro anti-sickling activities and phytochemical evaluation of Plumbago zeylanica and Uvaria chamae Olufunmilayo. Afr J Biotechnol 9(53):9032–9036Google Scholar
  4. Adejumo OE, Agbanah OIS, Kolapo AL, Ayoola MD (2011a) Phytochemical and anti-sickling activities of Entandrophragma utile, Chenopodium ambrosioides and Petiveria alliacea. J Med Plants Res. 5(9):1531–1535Google Scholar
  5. Adejumo OE, Ayoola MD, Kolapo AL, Orimoyegun VO, Olatunji PO (2011b) Anti-sickling activities of extracts of leaf, seed and seed pod of Garcinia kola Heckel. Afr J Pharm Pharmacol 5(1):48–52CrossRefGoogle Scholar
  6. Adesanya SA, Idowu TB, Elujoba AA (1988) Anti-sickling activity of Adansonia digitata. Planta Med 54(4):374PubMedCrossRefGoogle Scholar
  7. Afolabi IS, Osikoya IO, Fajimi OD, Usoroh PI, Ogunleye DO, Bisi-Adeniyi T, Adeyemi AO, Adekeye BT (2012) Solenostemon monostachyus, Ipomoea involucrate and Carica papaya (seed oil) versus Glutathione, or Vernonia amygdalina: methanolic extract of novel plants for the management of sickle cell anemia disease. BMC Complement Altern Med 12:262–271PubMedPubMedCentralCrossRefGoogle Scholar
  8. Akinsulie AO, Temiye EO, Akanmu AS, Lesi FE, Whyte CO (2005) Clinical evaluation of extract of Cajanus cajan (Ciklavit) in sickle cell anaemia. J Trop Pediatr 51(4):200–205PubMedCrossRefGoogle Scholar
  9. Ameh SJ, Tarfa FD, Ebeshi BU (2012) Traditional herbal management of sickle cell anemia: lessons from Nigeria. Anemia 2012:1–9CrossRefGoogle Scholar
  10. Anand V (2015) An updated review of Terminalia catappa. Pharmacol Rev 9(18):93–98CrossRefGoogle Scholar
  11. Arunachalam KD (2010) Anti-inflammatory and cytotoxic effects of extract from Plumbago zeylanica. Afr J Microbiol Res 4(12):1239–1245Google Scholar
  12. Ayoola AO, Akinloye O, Oguntibeju OO, Oke JM, Odetola AA (2011) Antioxidant activities of Parquetina nigrescens. Afr J Biotechnol 10(24):4920–4925Google Scholar
  13. Bharali R, Tabassum J, Azad MR (2003) Chemomodulatory effect of Moringa oleifera, Lam on hepatic carcinogen metabolizing enzymes, antioxidant parameters and skin papillomagenesis in mice. Asian Pac J Cancer Prev 4:131–139PubMedGoogle Scholar
  14. Booth C, Inusa B, Obaro SK (2010) Infection in sickle cell disease: a review. Int J Infect Dis 14(1):e2–e12PubMedCrossRefGoogle Scholar
  15. Caceres A, Cabrere O, Morales O, Mollinedo P, Mendia P (1991) Pharmacological properties of Moringa oleifera. 1: preliminary screening for antimicrobial activity. J Ethnopharmacol 33:213–216PubMedCrossRefGoogle Scholar
  16. Cáceres A, Saravia A, Rizzo S, Zabala L, De Leon E, Nave F (1992) Pharmacologic properties of Moringa oleifera. 2: Screening for antispasmodic, anti-inflammatory and diuretic activity. J Ethnopharmacol 36:233–237PubMedCrossRefGoogle Scholar
  17. Corrêa GM, Alcântara AFDC (2012) Chemical constituents and biological activities of species of Justicia—a review. Braz J Pharmacogn 22(1):220–238CrossRefGoogle Scholar
  18. Dash BP, Archana Y, Satapathy N, Naik SK (2013) Search for antisickling agents from plants. Pharmacogn Rev 7(13):53–60PubMedPubMedCentralCrossRefGoogle Scholar
  19. Dawodu AO, Moses UD, Apena A, Adetoro A, Dairo JO (2014) The proximate evaluation and phytochemistry of Enantia chlorantha stem bark in aqueous and ethanolic extract. Middle-East J Sci Res 21(11):2145–2148Google Scholar
  20. Desai AM. Herbomineral formulation for treating sickle cell disease. US20100189814. A1Google Scholar
  21. Egunyomi A, Moody JO, Eletu OM (2009) Anti-sickling activities of two ethnomedicinal plant recipes used for the management of sickle cell anaemia in Ibadan Nigeria. Afr J Biotechnol 8:20–25Google Scholar
  22. Ejele AE, Akpan IO, Ogukwe CE, Onyeocha VO, Ukiwe LN (2012) Bioassay-guided isolation and partial characterization of an anti-sickling compound from Enantia chlorantha. Int Res J Biochem Bioinforma 2(7):149–154Google Scholar
  23. Elekwa I, Monanu MO, Anosike EO (2005) Effects of aqueous extracts of Zanthoxylum macrophylla roots on membrane stability of human erythrocytes of different genotypes. Biokemistri 17(1):7–12Google Scholar
  24. Fabiyi OA, Atolani O, Adeyemi OS, Olatunji GA (2012) Antioxidant and cytotoxicity of β-amyrin acetate fraction from Bridelia ferruginea Leaves. Asian Pac J Trop Biomed 2(2):S981–S984CrossRefGoogle Scholar
  25. Fall AB, Fastré RV, Vanhaelen M, Lo I, Toppet M, Ferster A, Fondu P (1999) In vitro anti-sickling activity of a rearranged limonoid isolated from Khaya senegalensis. Planta Med 65(3):209–212PubMedCrossRefGoogle Scholar
  26. Farombi EO, Owoeye O (2011) Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid. Int J Environ Res Public Health 8:2533–2555PubMedPubMedCentralCrossRefGoogle Scholar
  27. Fastre VR, Vahaelen M, Lo I, Toppet M, Ferster A, Fondu P (1999) In vitro antisickling activity of a rearranged limonoid isolated from Khaya senegalensis. Planta Med 65(3):209–212CrossRefGoogle Scholar
  28. Folashade KO, Omoregie EH (2013) Chemical constituents and biological activity of medicinal plants used for the management of sickle cell disease-A review. J Med Plants Res 7(48):3452–3476Google Scholar
  29. Haq MZU, Ahmad S, Amarowicz R, Feo VD (2013) Antioxidant activity of the extracts of some cowpea (Vigna unguiculata (L) Walp.) cultivars commonly consumed in Pakistan. Mole 18:2005–2017CrossRefGoogle Scholar
  30. Hernández JMJF, Santiago OG, Cabrera MAR, Ferriño PCE, Corona MDRC (2016) Chemistry and pharmacology of citrus sinensis. Molecules 21(247):1–24Google Scholar
  31. Ibrahim H, Sani FS, Danladi BH, Ahmadu AA (2007) Phytochemical and anti-sickling studies of leaves of Hymenocardia acida. Pakistan J Biol Sci 10(5):788–791CrossRefGoogle Scholar
  32. Ibrahim H, Mdau BB, Ahmed A, Ilyas M (2011) Anthraquinones of Cissus populnea Guill & Perr (Amplidaceae). Afr J Tradit Complement Altern Med 8(2):140–143PubMedCrossRefGoogle Scholar
  33. Imaga NOA, Gbenle GO, Okochi VI, Adenekan SO, Edeoghon SO, Kehinde MO, Bamiro SB, Ajiboye A, Obinna A (2010) Anti-sickling and toxicological profiles of leaf and stem of Parquetina nigrescens L. J Med Plants Res 4(8):639–643Google Scholar
  34. Iweala EEJ, Uhegbu FO, Ogu GN (2010) Preliminary in vitro antisickling properties of crude juice extracts of Persia americana, Citrus sinensis, Carica papaya and Ciklavit. Afr J Tradit Complement Altern Med 7(2):113–117CrossRefGoogle Scholar
  35. John TA, Onabanjo AO (2010) Effect of an aqueous extract of Entandrophragma utile bark on gastric acid secretion in rat and isolated ileum contractility in guinea pig. Afr J Biomed Res 13:197–206Google Scholar
  36. Kaboré D, Lingani HS, Diawara B, Compaoré CS, Dicko MH, Jakobsen M (2011) A review of baobab (Adansonia digitata) products: effect of processing techniques, medicinal properties and uses. Afr J Food Sci 5(16):833–844Google Scholar
  37. Kubec R, Musah RA (2001) Cysteine sulfoxide derivatives in Petiveria alliacea. Phytochemistry 58:981–985PubMedCrossRefGoogle Scholar
  38. Kubec R, Kim S, Musah RA (2002) S-Substituted cysteine derivatives and thiosulfinate formation in Petiveria alliacea-Part II. Phytochemistry 61:675–680PubMedCrossRefGoogle Scholar
  39. Li X, Wang H, Liu C, Chen R (2010) Chemical constituents of Acacia catechu. Zhongguo Zhong Yao Za Zhi 35(11):1425–1427PubMedGoogle Scholar
  40. Maisarah AM, Amira NB, Asmah R, Fauziah O (2013) Antioxidant analysis of different parts of Carica papaya. Int Food Res J 20(3):1043–1048Google Scholar
  41. Marlier M, Guellec GL, Lognay G, Wathelet JP, Severin M (1993) Characterization of three labdane diterpenes from Aframomum alboviolaceum. Planta Med 59(5):455–457PubMedCrossRefGoogle Scholar
  42. Mbata TI, Debiao LU, Saikia A (2008) Antibacterial activity of the crude extract of Chinese green tea (Camelia sinensis) on listeria monocytogenes. Afr J Biotechnol 7(10):1571–1573Google Scholar
  43. Meira M, Silva EPD, David JM, David JP (2012) Review of the genus Ipomoea: traditional uses, chemistry and biological activities. Braz J Pharmacogn 22(3):682–713CrossRefGoogle Scholar
  44. Mgbemene CN, Ohiri FC (1999) Anti-sickling potential of Terminalia catappa leaf extract. J Pharma Biol 37(2):152–154CrossRefGoogle Scholar
  45. Mojisola OC, Adebolu EA, Alani DM (2008) Anti-sickling properties of Carica papaya Linn. J Nat Prod 1:56–66Google Scholar
  46. Monago CC, Uwakwe AA (2008) Proximate composition and in-vitro anti sickling property of Nigerian Cyperus esculentus (tiger nut sedge). Trees Life J 4(2):1–6Google Scholar
  47. Monzote L, Nance MR, García M, Scull R, Setzer WN (2011) Comparative chemical, cytotoxicity and antileishmanial properties of essential oils from Chenopodium ambrosioides. Nat Prod Commun 6(2):281–286PubMedGoogle Scholar
  48. Moody JO, Ojo O, Omotade OO, Adeyemo AA, Olusese PE, Ogundipe A (2003) Anti-sickling potential of a Nigerian herbal formular and the major plant component (Cissus populnea L. CPK). Phytother Res 10:1137–1176Google Scholar
  49. Mpiana PT, Mudogo V, Tshibangu DST, Ngbolua KN, Shetonde OM, Mangwala KP, Mavakala BK (2007) In vitro anti-sickling activity of anthocyanins extract of a Congolese plant: Alchornea cordifolia M. Arg. J Med Sci 7(7):1182–1186CrossRefGoogle Scholar
  50. Mpiana PT, Ngbolua KTNN, Bokota MT, Kasonga TK, Atibu EK, Tshibangu DST, Mudogo V (2010) In vitro effects of anthocyanin extracts from Justicia secunda Vahl on the solubility of Haemoglobin S and membrane stability of sickle erythrocytes. Blood Transfus 8(4):248–254PubMedPubMedCentralGoogle Scholar
  51. Mpiana PT, Dianzenza EN, Ngbolua KN, Tshibangu DST, Mbala BM, Mhigo SO, Atibu EK, Kakule MK, Bokota MT (2012) Antisickling properties, thermal and photochemical degradations of anthocyanin extracts from Annona senegalensis (Annonaceae). Int J Biol Chem Sci 6(5):2241–2251Google Scholar
  52. Nwaoguikpe RN (2010) The phytochemical, proximate and amino acid compositions of the extracts of two varieties of tiger nut (Cyperus esculentus) and their effects on sickle cell hemoglobin polymerization. J Med Med Sci 1(11):543–549Google Scholar
  53. Nwaoguikpe RN, Braide W, Ezejiofor TIN (2010) The effect of Aloe vera plant (Aloe barbadensis) extracts on sickle cell blood (HbSS). Afr J Food Sci Technol 1(3):58–63Google Scholar
  54. Ogoda OJ, Akubue PI, Okide GB (2002) The kinetics of reversal of pre-sickled erythrocytes by the aqueous extract of Cajanus cajan seeds. Phytother Res 16(8):748–750CrossRefGoogle Scholar
  55. Ohnishi ST, Ohnishi T, Ogunmola GB (2000) Sickle cell anemia: a potential nutritional approach for a molecular disease. Nutrition 16(5):330–338PubMedCrossRefGoogle Scholar
  56. Okwu DE, Iroabuchi F (2009) Phytochemical composition and biological activities of Uvaria chamae and Clerodendron splendens. E J Chem 6(2):553–560CrossRefGoogle Scholar
  57. Okwu DE, Ukanwa N (2010) Isolation, characterization and antibacterial activity screening of anthocyanidin glycosides from Alchornea cordifolia (Schumach. and Thonn.) Mull. Arg. leaves. E J Chem 7(1):41–48CrossRefGoogle Scholar
  58. Otunola GO, Oloyede OB, Oladiji AT, Afolayan AJ (2010) Comparative analysis of the chemical composition of three spices–Allium sativum L., Zingiber officinale Rosc. and Capsicum frutescens L. commonly consumed in Nigeria. Afr J Biotechnol 9(41):6927–6931Google Scholar
  59. Owolabi MA, Coker HAB, Jaja SI (2010) Bioactivity of the phytoconstituents of the leaves of Persea Americana. J Med Plants Res. 4(12):1130–1135Google Scholar
  60. Panigrahi HK, Kushawa H, Sharma SS (1997) Treatment of sickle cell disorders by ayurvedic medicine. Anc Sci Life 17(1):15–22PubMedPubMedCentralGoogle Scholar
  61. Parise LV, Berliner N (2016) Sickle cell disease: challenges and progress. Blood J 127(7):789CrossRefGoogle Scholar
  62. Roseff SD (2009) Sickle cell disease: a review. Immunohematology 25(2):67–74PubMedGoogle Scholar
  63. Sahu M, Singh V, Yadav S, Harris KK (2012) Plant extracts with antisickling propensities: a feasible succour towards sickle cell disease management- a mini review. J Phytology 4(3):24–29Google Scholar
  64. Salkar K, Suthar A, Chotalia C (2014) Study of immunomodulatory activity of Tinospora cordifolia extract. Int J Adv Pharma Biol Chem 3(4):880–883Google Scholar
  65. Simeone EI, Tufon EN, Victor ON, Noel NN (2012) Anti-sickling potential of the ethanol seed extracts of Vigna unguiculata and Vigna subterranean. Int J Biochem Biotechnol 1(9):226–229Google Scholar
  66. Soforowa EA (1975) Isolation and characterization of an anti-sickling agent from Fagara zanthoxyloides. Lloydia 38:169–171Google Scholar
  67. Sulaiman CT, Gopalakrishnan VK (2013) Radical scavenging and in vitro hemolytic activity of aqueous extracts of selected acacia species. J Appl Pharma Sci 3(3):109–111Google Scholar
  68. Sulaiman MR, Zakaria ZA, Bujarimin AS, Somcent MN, Israf DA, Moin S (2008) Evaluation of Moringa oleifera aqueous extract for antinociceptive and anti-inflammatory activities in animal models. Pharm Biol 46:838–845CrossRefGoogle Scholar
  69. Takasu J, Uykimpang R, Sunga M, Amagase H, Niihara Y (2002) Aged garlic extract therapy for sickle cell anemia patients. BMC Blood Disord 2(1):1–3Google Scholar
  70. Uwakwe AA, Nwaoguikpe RN (2008) In vitro anti-sickling effects of Xylopia aethiopica and Monodora myristica. J Med Plants Res. 2(6):119–124Google Scholar
  71. Yisa J, Egila JN, Darlinton AO (2010) Chemical composition of Annona senegalensis from Nupe land, Nigeria. Afr J Biotechnol 9(26):4106–4109Google Scholar
  72. Zhang L, Tizard IR (1996) Activation of a mouse macrophage cell line by acemannan: The major carbohydrate fraction from Aloe vera gel. Immunopharmacology 35(2):119–128PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Shweta Jain
    • 1
  • Ankur Vaidya
    • 2
  • Kamal Shah
    • 3
  • Durgesh Nandini Chauhan
    • 4
  • Nagendra Singh Chauhan
    • 5
  1. 1.Pharmacy CollegeSir Madanlal Group of InstituteEtawahIndia
  2. 2.Pharmacy CollegeUttar Pradesh University of Medical SciencesSaifai, EtawahIndia
  3. 3.Institute of Pharmaceutical ResearchGLA UniversityMathuraIndia
  4. 4.Columbia Institute of PharmacyRaipurIndia
  5. 5.Drugs Testing Laboratory Avam Anusandhan KendraRaipurIndia

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