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Ajwa Dates: A Highly Nutritive Fruit with the Impending Therapeutic Application

  • Muqtadir Baig Mirza
  • Fareeduddin Quadri Syed
  • Fazal Khan
  • Ayman I. Elkady
  • Atef M. Al-Attar
  • Khalid Rehman Hakeem
Chapter

Abstract

Phoenix dactylifera L. (Figure 1), also known as date palm, is well known for its nutritive value around the world and consumed in Arabian peninsula as an essential diet. It has been mentioned in prophetic, traditional, and alternative medicine. Its fruits, seeds, pollen, and leaves have antioxidant, antidiabetic, anticancer, antimicrobial, antihyperlipidemic, hepatoprotective, nephroprotective, neuroprotective, gastrointestinal, and sexual improvement properties. The important pharmacological properties of the date palm have been attributed to potent constituents including flavonoids, phenolics, carotenoids, minerals, vitamins, amino acids, organic acids, and fatty acids. Date fruit also increases estrogen, testosterone, PCV, and Hb levels. According to Islamic hadith (Prophet’s saying), Saud (R.A.) narrated that I heard Prophet Mohammad (SAWS) saying, “If Somebody takes seven Ajwa dates (Figure 2) in the morning, neither magic nor poison will hurt him that day.” By keeping all the detailed information in view, it can be concluded that dates are ideal food, providing multiple essential nutrients and potential health benefits.

Keywords

Phoenix dactylifera Nutritional value Phytochemicals Pharmacological activity Ajwa dates 

References

  1. Abbas FA, Ateya A-M (2011) Estradiol, esteriol, estrone and novel flavonoids from date palm pollen. Aust J Basic Appl Sci 5(8):606–614Google Scholar
  2. Abdelaziz DHA, Ali SA (2014) The protective effect of Phoenix dactylifera L. seeds against CCl4-induced hepatotoxicity in rats. J Ethnopharmacol 155(1):736–743.  https://doi.org/10.1016/j.jep.2014.06.026 PubMedGoogle Scholar
  3. Abdelaziz DHA, Ali SA, Mostafa MMA (2015) Phoenix dactylifera seeds ameliorate early diabetic complications in streptozotocin-induced diabetic rats. Pharm Biol 53(6):792–799. http://www.ncbi.nlm.nih.gov/pubmed/25612778 PubMedGoogle Scholar
  4. Abdul E, Assirey R (2015) Nutritional composition of fruit of 10 date palm (Phoenix dactylifera L.) cultivars grown in Saudi Arabia. Integr Med Res 9(1):75–79.  https://doi.org/10.1016/j.jtusci.2014.07.002 Google Scholar
  5. Abdullah YA (2008) Possible anti-diarrhoeal effect of the date palm (Phoenix dactylifera L.) spathe aqueous extract in rats. Group 9(1):131–138Google Scholar
  6. Agbon AN, Ingbian SD, Dahiru AU (2014) Preliminary histological and histochemical studies on the neuroprotective effect of aqueous fruit extract of Phoenix dactylifera L. (date palm) on atesunate-induced cerebellar damage in Wistar rats. Sub-Saharan Afr J Med 1(4):204–209Google Scholar
  7. Ahmed AF et al (2015) Proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity. J Med Food 18(3):280–289. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4350264&tool=pmcentrez&rendertype=abstract
  8. Ahmed S (2016) Anti hyperlipidemic and hepatoprotective effects of native date fruit variety Aseel (Phoenix dactylifera). Pak J Pharm Sci 29:1945–1950PubMedGoogle Scholar
  9. Ahmed A, Bano N, Tayyab M (2016) Phytochemical and therapeutic evaluation of date (Phoenix dactylifera). A review. J Pharm Alternat Med 9 (November 2015), 11–17Google Scholar
  10. Al-Farsi MA, Lee CY (2008) Nutritional and functional properties of dates: a review. Crit Rev Food Sci Nutr 48(10):877–887PubMedGoogle Scholar
  11. Al-Farsi M et al (2005) Compositional and sensory characteristics of three native sun-dried date (Phoenix dactylifera L.) varieties grown in Oman. J Agric Food Chem 53(19):7586–7591PubMedGoogle Scholar
  12. Ali Haimoud S, Allem R, Merouane A (2016) Antioxidant and anti-inflammatory properties of widely consumed date palm (Phoenix dactylifera L.) fruit varieties in Algerian Oases. J Food Biochem 40(4):463–471Google Scholar
  13. Al-Kuran O et al (2011) The effect of late pregnancy consumption of date fruit on labour and delivery. J Obstet Gynaecol 31(1):29–31PubMedGoogle Scholar
  14. Al-Qarawi AA, Ali BH, Al-Mougy SA, Mousa HM (2003) Gastrointestinal transit in mice treated with various extracts of date (Phoenix dactylifera L.). Food Chem Toxicol 41(1):37–39. http://www.sciencedirect.com/science/article/pii/S027869150200203X PubMedGoogle Scholar
  15. Al-Qarawi A et al (2004) Protective effect of extracts from dates (Phoenix dactylifera L.) on carbon tetrachloride-induced hepatotoxicity in rats. Int J Appl Res Vet Med 2(3):176–180. http://jarvm.com/articles/Vol2Iss3/ELMOUGHJARVMVol2No304.pdf Google Scholar
  16. Al-Qarawi AA et al (2005) The ameliorative effect of dates (Phoenix dactylifera L.) on ethanol-induced gastric ulcer in rats. J Ethnopharmacol 98(3):313–317PubMedGoogle Scholar
  17. Al-Qarawi AA et al (2008) Nephroprotective action of Phoenix dactylifera in gentamicin-induced nephrotoxicity. Pharm Biol 46(4):227–230. http://www.scopus.com/inward/record.url?eid=2-s2.0-41349116154&partnerID=tZOtx3y1 Google Scholar
  18. Al-Shahib W, Marshall RJ (2002) Dietary fibre content of dates from 13 varieties of date palm Phoenix dactylifera L. Int J Food Sci Technol 37(6):719–721Google Scholar
  19. Al-Shahib W, Marshall RJ (2003) The fruit of the date palm: its possible use as the best food for the future? Int J Food Sci Nutr 54(4):247–259PubMedGoogle Scholar
  20. Ardekani MRS, Khanavi M, Hajimahmoodi M, Jahangiri M, Hadjiakhoondi A (2010) Comparison of antioxidant activity and total phenol contents of some date seed varieties from Iran. Iran J Pharmaceut Res 9(2):141–146Google Scholar
  21. Ateeq A, Dutta Sunil S, Varun SK, Santosh MK (2013) Phoenix dactylifera Linn. (Pind Kharjura): a review. Int J Res Ayurveda Pharm 4(3):447–451Google Scholar
  22. Atta H, Abo-EL-Sooud K, Ahmed SS, Ibrahim S, Zaher S (2015) Synergistic hepatoprotective effect of grape juice with date palm fruit methanolic extracts. Wulfenia J 22(12):282–297Google Scholar
  23. Baharara J et al (2015) Protective effect of date palm pollen (Phoenix dactylifera) on sperm parameters and sexual hormones in male NMRI mice exposed to low frequency electromagnetic field (50 Hz). J Herbmed Pharmacol 4(3):75–80Google Scholar
  24. Baliga MS et al (2011) A review of the chemistry and pharmacology of the date fruits (Phoenix dactylifera L.). Food Res Int 44(7):1812–1822.  https://doi.org/10.1016/j.foodres.2010.07.004 Google Scholar
  25. Bokhari NA, Perveen K (2012) In vitro inhibition potential of Phoenix dactylifera L. extracts on the growth of pathogenic fungi. J Med Plants Res 6(6):1083–1088. http://www.academicjournals.org/journal/JMPR/article-abstract/8C79E5325796
  26. Borchani C, Besbes S, Blecker C, Masmoudi M, Baati R, Attia H (2010) Chemical properties of 11 date cultivars and their corresponding fiber extracts. Afr J Biotechnol 9(12):4096–4105. http://www.ajol.info/index.php/ajb/article/view/82578
  27. Boudries H, Kefalas P, Hornero-Méndez D (2007) Carotenoid composition of Algerian date varieties (Phoenix dactylifera) at different edible maturation stages. Food Chem 101(4):1372–1377Google Scholar
  28. Bouhlali ET et al (2016) Evaluation of antioxidant, antihemolytic and antibacterial potential of six Moroccan date fruit (Phoenix dactylifera L.) varieties. J King Saud Univ Sci 28(2):136–142.  https://doi.org/10.1016/j.jksus.2016.01.002 Google Scholar
  29. Bouhlali EDT, Ramchoun M, Alem C, Ghafoor K, Ennassir J, Zegzouti YF (2015) Functional composition and antioxidant activities of eight Moroccan date fruit varieties (Phoenix dactylifera L.). J Saudi Soc Agric Sci (September)Google Scholar
  30. Chaira N et al (2009) Simple phenolic composition, flavonoid contents and antioxidant capacities in water-methanol extracts of Tunisian common date cultivars (Phoenix dactylifera L.). Int J Food Sci Nutr 60(Suppl 7):316–329. http://www.ncbi.nlm.nih.gov/pubmed/19736597 PubMedGoogle Scholar
  31. Chakroun M et al (2016) Evaluation of anti-diabetic and anti-tumoral activities of bioactive compounds from Phoenix dactylifera L’s leaf: in vitro and in vivo approach. Biomed Pharmacother 84:415–422.  https://doi.org/10.1016/j.biopha.2016.09.062 PubMedGoogle Scholar
  32. Duke JA (2001) Handbook of phytochemical constituents of GRAS herbs and other economic plants. CRC Press, Boca Raton, FLGoogle Scholar
  33. Duke JA, Beckstrom-Sternberg S (2007) Dr. Duke’s Ethnobotanical databses. http://www.ars-grin.gov/duke/plants.html
  34. Eid NMS et al (2013) Effect of cultivar type and ripening on the polyphenol content of date palm fruit. J Agric Food Chem 61(10):2453–2460PubMedGoogle Scholar
  35. Eid N et al (2014) The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation. J Nutr Sci 3(22):e46. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4473134&tool=pmcentrez&rendertype=abstract
  36. El Arem A, Ghrairi F et al (2014a) Hepatoprotective activity of date fruit extracts against dichloroacetic acid-induced liver damage in rats. J Funct Foods 9(1):119–130.  https://doi.org/10.1016/j.jff.2014.04.018 Google Scholar
  37. El Arem A, Zekri M et al (2014b) Oxidative damage and alterations in antioxidant enzyme activities in the kidneys of rat exposed to trichloroacetic acid: protective role of date palm fruit. J Physiol Biochem 70(2):297–309PubMedGoogle Scholar
  38. El-Gazzar UB, El-Far AH, Abdel Maksoud HA (2009) The ameliorative effect of Phoenix dactylifera extract on CCl4 hepatotoxicity in New Zealand rabbits. J Appl Sci Res 5(9):1082–1087Google Scholar
  39. Elleuch M et al (2008) Date flesh: chemical composition and characteristics of the dietary fibre. Food Chem 111:676–682Google Scholar
  40. El-Neweshy MS, El-Maddawy ZK, El-Sayed YS (2013) Therapeutic effects of date palm (Phoenix dactylifera L.) pollen extract on cadmium-induced testicular toxicity. Andrologia 45(6):369–378PubMedGoogle Scholar
  41. FAO (2007) Statistical databases. http://faostat.fao.org. Accessed 2 June 2007
  42. Farag El-Kott A, Ali Sayed A, El-Sayad SM, Abdoulrahman MH (2014) The pharmaceutical effect of date palm fruit extract (Phoenix dactylifera L.) against Amitraz-induced infertility in male rats. Adv Life Sci Technol 22:14–27Google Scholar
  43. Farouk A, Metwaly A, Mohsen M (2015) Chemical composition and antioxidant activity of date palm pollen grains (Phoenix dactylifera L. Palmae) essential oil for Siwe cultivar cultivated in Egypt. Middle East J Appl Sci 5:945–949Google Scholar
  44. Hafez El-Far A et al (2016) Date palm (Phoenix dactylifera): protection and remedy food. Curr Trends Nutraceuticals 1:2Google Scholar
  45. Hamad I et al (2015) Metabolic analysis of various date palm fruit (Phoenix dactylifera L.) cultivars from Saudi Arabia to assess their nutritional quality. Molecules 20(8):13620–13641PubMedPubMedCentralGoogle Scholar
  46. Hasan M, Mohieldein A (2016) In vivo evaluation of anti diabetic, hypolipidemic, antioxidative activities of Saudi date seed extract on streptozotocin induced diabetic rats. J Clin Diagn Res 10(3):6–12Google Scholar
  47. Hong YJ, Tomas-Barberan FA, Kader AA, Mitchell AE (2006) The flavonoid glycosides and procyanidin composition of Deglrt Noor Dates (Pheonix dactylifera). J Agric Food Chem 54:2405–2411PubMedGoogle Scholar
  48. Ishurd O, Zahid M, Xiao P, Pan Y (2004) Protein and amino acids contents of libyan dates at three stages of development. J Sci Food Agric 84(5):481–484Google Scholar
  49. Jassim SAA, Naji MA (2010) In vitro evaluation of the antiviral activity of an extract of date palm (Phoenix dactylifera L.) pits on a Pseudomonas phage. Evid Based Complement Alternat Med 7(1):57–62PubMedGoogle Scholar
  50. Kchaou W et al (2016) Phenolic profile, antibacterial and cytotoxic properties of second grade date extract from Tunisian cultivars (Phoenix dactylifera L.). Food Chem 194:1048–1055.  https://doi.org/10.1016/j.foodchem.2015.08.120 PubMedGoogle Scholar
  51. Kehili HE, Zerizer S, Beladjila KA, Kabouche Z (2016) Anti-inflammatory effect of Algerian date fruit (Phoenix dactylifera). Food Agric Immunol 27(6):820–829. https://www.tandfonline.com/doi/full/10.1080/09540105.2016.1183597 Google Scholar
  52. Khalid S et al (2016) Nutritional assessment of Ajwa date flesh and pits in comparison to local varieties. J Anim Plant Sci 26(4):1072–1080Google Scholar
  53. Khan F, Ahmed F, Natesan Pushparaj P, Abuzenadah A (2016a) Ajwa date (Phoenix dactylifera L.) extract inhibits human breast adenocarcinoma (MCF7) cells in vitro by inducing apoptosis and cell cycle arrest. PLoS One 11:1–17Google Scholar
  54. Khan SA et al (2016b) In vitro inhibitory effects on α-glucosidase and α-amylase level and antioxidant potential of seeds of Phoenix dactylifera L. Asian Pac J Trop Biomed 6(4):322–329Google Scholar
  55. δάκτυλος. Liddell, Henry George; Scott, Robert; A Greek–English Lexicon at the Perseus Proj- ect.Google Scholar
  56. Louaileche H, Hammiche D, Hamoudi F (2015) Total phenolic, flavonoid contents and in vitro antioxidant activity of Algerian date palm varieties: a comparative study. Am J Food Sci Health 1(3):63–68Google Scholar
  57. Mansour AM, Ghobara MY (2015) Abrogation of cisplatin-induced nephrotoxicity in rats by Berne date extract through ameliorating oxidative stress, inflammation and apoptosis. Int J Ther Appl 6(9):1226–1233Google Scholar
  58. Mansouri A, Embarek G, Kokkalou E, Kefalas P (2005) Phenolic profile and antioxidant activity of the Algerian ripe date palm fruit (Phoenix dactylifera). Food Chem 89(3):411–420Google Scholar
  59. Mehraban F et al (2014) Effects of date palm pollen (Phoenix dactylifera L.) and Astragalus ovinus on sperm parameters and sex hormones in adult male rats. Iran J Reprod Med 12(10):705–712PubMedPubMedCentralGoogle Scholar
  60. Nair MG (2013) Antioxidant and anti-inflammatory assays confirm bioactive compounds in Ajwa date fruit. J Agric Food Chem 61:5834–5840PubMedGoogle Scholar
  61. Orabi SH, Shawky SM (2014) Effect of date palm (Phoenix dactylifera) seeds extracts on hematological, biochemical parameters and some fertility indices in male rats. Int J Sci Basic Appl Res (IJSBAR) 17(1):137–147Google Scholar
  62. Ragab AR, Elkablawy MA, Sheik BY, Baraka HN (2012) Antioxidant and tissue-protective studies on Ajwa extract: dates from Al-Madinah Al-Monwarah, Saudia Arabia. J Environ Anal Toxicol 3(1):1–8Google Scholar
  63. Ranilla LG et al (2008) Antidiabetes and antihypertension potential of commonly consumed carbohydrate sweeteners using in vitro models. J Med Food 11(2):337–348 http://www.ncbi.nlm.nih.gov/pubmed/18598178 PubMedGoogle Scholar
  64. Saafi EB et al (2011) Protective effect of date palm fruit extract (Phoenix dactylifera L.) on dimethoate induced-oxidative stress in rat liver. Exp Toxicol Pathol 63(5):433–441  https://doi.org/10.1016/j.etp.2010.03.002 PubMedGoogle Scholar
  65. Saleh EA, Tawfik MS, Abu-tarboush HM (2011) Phenolic contents and antioxidant activity of various date palm (Phoenix dactylifera L.) fruits from Saudi Arabia. Food Nutr Sci 2:1134–1141Google Scholar
  66. Shafiei M, Karimi K, Taherzadeh MJ (2010) Palm date fibers: analysis and enzymatic hydrolysis. Int J Mol Sci 11(11):4285–4296PubMedPubMedCentralGoogle Scholar
  67. Sheikh BY et al (2016) Comparative study of neuropharmacological, analgesic properties and phenolic profile of Ajwah, Safawy and Sukkari cultivars of date palm (Phoenix dactylifera). Orient Pharm Exp Med 16:175–183.  https://doi.org/10.1007/s13596-016-0239-5 PubMedPubMedCentralGoogle Scholar
  68. Souli A et al (2014) Effects of dates pulp extract and palm sap (Phoenix dactylifera L.) on gastrointestinal transit activity in healthy rats. J Med Food 17(7):782–786 http://www.scopus.com/inward/record.url?eid=2-s2.0-84904326085&partnerID=tZOtx3y1 PubMedPubMedCentralGoogle Scholar
  69. Subash S et al (2015) Effect of dietary supplementation of dates in Alzheimer’s disease APPsw/2576 transgenic mice on oxidative stress and antioxidant status. Nutr Neurosci 18(6):281–288 http://www.ncbi.nlm.nih.gov/pubmed/24954036 PubMedGoogle Scholar
  70. Takaeidi MR et al (2014) The effect of date seed (Phoenix dactylifera) extract on paraoxonase and arylesterase activities in hypercholesterolemic rats. Jundishapur J Nat Pharm Prod 9(1):30–34PubMedPubMedCentralGoogle Scholar
  71. USDA. National Nutrient Database for Standard Reference, United States Department of Agriculture; www.nal.usda.gov/fnic/foodcomp/search/. Accessed 15 May 2007
  72. Whitney E, Rolfes S (2002) Understanding nutrition. Ninth edition. Wadsworth/Thomson Learning, Belmont, CAGoogle Scholar
  73. Zangiabadi N et al (2011) Date fruit extract is a neuroprotective agent in diabetic peripheral neuropathy in streptozotocin-induced diabetic rats: a multimodal analysis. Oxid Med Cell Longev 2011:976948PubMedPubMedCentralGoogle Scholar
  74. Zhang CR, Aldosari SA, Vidyasagar PSPV, Shukla P, & Nair MG (2017) Health-benefits of date fruits produced in Saudi Arabia based on in vitro antioxidant, anti-inflammatory and human tumor cell proliferation inhibitory assays. J Saudi Soc Agric Sci 16(3):287–293.  https://doi.org/10.1016/j.jssas.2015.09.004 Google Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Muqtadir Baig Mirza
    • 1
  • Fareeduddin Quadri Syed
    • 1
  • Fazal Khan
    • 2
  • Ayman I. Elkady
    • 1
  • Atef M. Al-Attar
    • 1
  • Khalid Rehman Hakeem
    • 1
  1. 1.Department of Biological Sciences, Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia
  2. 2.Department of Genetics and Molecular MedicineKamineni HospitalHyderabadIndia

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