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Hepatocellular Cancer Induced by Infection

  • David E. KaplanEmail author
  • Kyong-Mi ChangEmail author
  • Arun Sanyal
Chapter
Part of the Current Cancer Research book series (CUCR)

Abstract

Hepatocellular carcinoma is the fifth most common cancer and second leading cause of cancer death worldwide. Chronic viral infections contribute to approximately three-fourths of these cancers either as direct carcinogens or indirectly mediated through progressive hepatic fibrosis and cirrhosis. Bacteria, specifically the gut microbiome, also contributes to the in the genesis of hepatocellular carcinoma. Obesity-related nonalcoholic fatty liver disease and alcoholic liver disease, the major non-viral causes of chronic liver disease predisposing to liver cancer, alter the composition of the gut microbiome, which appears to foster development and progression of pre-malignant and malignant liver neoplasms. Emerging data implicates patterns of dysbiosis with alterations of bile acid metabolism, insulin resistance, fibrogenesis, and gut barrier integrity that contribute to intrahepatic inflammatory signaling and carcinogenesis. In vitro, small animal model, and human data supporting the role of chronic viral infection and bacterial derangements in hepatocarcinogenesis will be reviewed.

Keywords

Hepatocellular carcinoma Cirrhosis Microbiome Hepatitis B Hepatitis C Alcohol Toll-like receptors Bacterial translocation Bile acids 

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of GastroenterologyUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaUSA
  2. 2.Section of GastroenterologyCorporal Michael J. Crescenz VA Medical CenterPhiladelphiaUSA
  3. 3.Division of GastroenterologyVirginia Commonwealth UniversityRichmondUSA

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