Heat Shock Proteins, Exercise and Inflammation

  • Fabiano T. AmorimEmail author
  • Micah N. Zuhl
Part of the Heat Shock Proteins book series (HESP, volume 17)


The heat shock response (HSR) plays a regulatory role in controlling inflammatory events within a cell. The activation/induction and interplay of heat shock factor 1 (HSF1) and heat shock proteins (HSP) have inhibitory effect on nuclear factor-kappa B (NFκB) inflammatory pathway, c-Jun N-terminal kinases (JNK) regulation, and preventing free radical damage. Exercise training induces the HSR and has the potential to reduce inflammation. The current chapter examines the regulatory impacts of the HSR on inflammation and the role of the HSR in chronic inflammatory disease states, such as skeletal muscle insulin resistance and ischemia/reperfusion injury of the myocardium. In addition, we discuss the inflammatory role of exercise training in activating the HSR, improving insulin signaling, reducing vasculature inflammation, and promoting cardioprotection against ischemia/reperfusion injury of the myocardium.


Cardioprotection Cardiovascular disease Free radical damage Insulin resistance Ischemia/reperfusion Type 2 diabetes mellitus 



protein kinase B


5′ adenosine monophosphate-activated protein kinase


activation protein-1


extracellular signal-regulated protein kinases 1 and 2


glucose transporter type 4


high intensity interval training


homeostasis model assessment index


heat shock factor 1


heat shock proteins


heat shock protein 27


heat shock protein 60


family of heat shock protein 70 kda

Hsp72 or HSPA1A

heat shock protein 72 kda


heat shock response


inhibitor of NF-κB kinase


interleukin-1 β


intramuscular triglyceride


insulin resistance


insulin receptor substrate 1


c-jun amino terminal kinase




mitogen activated protein kinase


nuclear factor-kappa B


oral glucose tolerance test


peripheral blood mononuclear cell


reactive nitrogen species


reactive oxygen species


type 2 diabetes mellitus


tumor necrosis factor-alpha


uncoupling protein 3





The authors acknowledge M.S. Roberto Nava for reviewing the chapter.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Exercise Science Program, Department of Health, Exercise, and Sports SciencesUniversity of New MexicoAlbuquerqueUSA

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