Heat Shock Response and Metabolism in Skeletal Muscle

  • Yuki TamuraEmail author
Part of the Heat Shock Proteins book series (HESP, volume 17)


Skeletal muscle comprises approximately 40% of the total body mass in humans. It plays important roles in locomotion, metabolism and endocrine signaling. We and others have previously described the biological responses/adaptations of skeletal muscle to heat stress, the contributions of heat shock proteins to the cellular processes underlying the muscle response to heat stress, and the therapeutic potential of manipulating heat stress and heat shock proteins in skeletal muscle. In this chapter, I briefly summarize current understanding of the heat stress-induced regulation of protein, glucose and mitochondrial metabolism in skeletal muscle. Furthermore, I overview future perspectives on studies of the heat shock response in skeletal muscle biology.


Atrophy Glucose Heat shock proteins Hypertrophy Mitochondria Skeletal muscle 



AMP-activated protein kinase


O-[3-piperidino-2-hydroxy-1-propyl]-nicotinic amidoxime


Ca2+/calmodulin-dependent protein kinase II


domain-containing mTOR-interacting protein


forkhead box O


glucose transporter


heat shock element


heat shock factor 1


heat shock protein


insulin-like growth factor 1


c-Jun N-terminal kinases


microtubule-associated proteins 1A/1B light chain 3


mitogen-activated protein kinase


mitofusion 2


MTOR associated protein


mechanistic target of rapamycin


nuclear respiratory factor


peroxisome proliferator-activated receptor gamma coactivator 1-alpha


protein phosphatase 2


peroxisome proliferator-activated receptor


proline-rich Akt substrate


regulatory-associated protein


reactive oxygen species


unfolded protein response


voltage-dependent anion channels



Yuki Tamura is the recipient of a post-doctoral fellowship from the Japan Society for the Promotion of Science, Tokyo, Japan.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Graduate School of Health and Sport ScienceNippon Sport Science UniversityTokyoJapan
  2. 2.Faculty of Sport ScienceNippon Sport Science UniversityTokyoJapan
  3. 3.Center for Coaching ExcellenceNippon Sport Science UniversityTokyoJapan
  4. 4.Research Institute for Sport ScienceNippon Sport Science UniversityTokyoJapan

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