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Heat Shock Proteins in Digestive Tract Cancer: Molecular Mechanism and Therapeutic Potential

  • Liang Wenjin
  • Li Zeming
  • Liao Yong
  • Wang Yan
  • Tang Bo
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 17)

Abstract

Heat Shock Proteins (HSP) are a category of proteins for stress regulation being highly conservative in respect of evolutionary sequence, which mainly consist of HSP10, HSP27, HSP40, HSP60, HSP70, HSP90, HSP110 and multiple sub-types thereof. The main function is to maintain the normal functional structure of proteins through the molecular chaperone role. Simultaneously, it can also play a role of cell protection and immunoregulation. The expression of HSP is extensively high in digestive tract cancer and closely related to multiple biological functions such as tumor cell proliferation, cell apoptosis, cell cycle, invasion and migration and drug resistance in chemical therapy, etc. Simultaneously, it has also verified that the inhibitor of HSP can resist the tumor promotion effect effectively in vitro and in vivo. However, the current researches are being concentrated on the inhibitors of HSP70 and HSP90. Further clinic research verification is also needed. In summary, HSP are not only potential tumor biomarkers in early diagnosis and prognosis monitoring to digestive tract cancer, but also a potential target for effective therapy to tumors.

Keywords

Clinical applications Digestive tract cancer Heat shock proteins Molecular mechanism Therapeutics 

Abbreviations

BDEC

bile duct epithelial cells

CCA

cholangiocarcinoma

CTL

cytotoxic T lymphocyte

ESCC

esophageal squamous cell cancer

HCC

hepatocellular carcinoma

HSP

heat shock proteins

Notes

Acknowledgments

We wish to particularly acknowledge Prof. He Songqing and Prof. Yang Jinghong. Department of Hepatobiliary Surgery, Guilin Medical University. And Prof. Ye Qifa. Institute of Hepatobiliary disease, Wuhan University. For they helped to revise the manuscript and make valuable Suggestions.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Liang Wenjin
    • 1
  • Li Zeming
    • 2
  • Liao Yong
    • 2
  • Wang Yan
    • 2
  • Tang Bo
    • 2
  1. 1.Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhanChina
  2. 2.Department of Hepatobiliary SurgeryGuilin Medical University, Affiliated HospitalGuilinPeople’s Republic of China

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