Contrast-Enhanced Ultrasound: The Current State

  • M. Beth McCarvilleEmail author
  • Annamaria Deganello
  • Zoltan Harkanyi
Part of the Pediatric Oncology book series (PEDIATRICO)


Contrast-enhanced ultrasound (CEUS) is being increasingly recognized as an important method of imaging a variety of adult malignancies involving the liver, breast, prostate, and kidneys. Children are the ideal patient population for CEUS for a number of reasons including avoidance of exposure to ionizing radiation and sedation. However, because these agents were initially approved for use only in adult cardiology, less is known of their potential value in children. In 2016, the United States Federal Drug Administration approved the first ultrasound contrast agent for use in imaging liver lesions in both adults and children. This approval ushers in a new era for the growth and development of CEUS in children in a number of clinical settings. In this chapter experts in pediatric CEUS from the United States and Europe will discuss the important safety and technical aspects of CEUS and describe their experience with this modality in the setting of pediatric oncology. Future directions of CEUS in pediatric oncology will be addressed.


Contrast-enhanced ultrasound Safety Pediatric Malignancies Treatment response 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • M. Beth McCarville
    • 1
    Email author
  • Annamaria Deganello
    • 2
  • Zoltan Harkanyi
    • 3
  1. 1.Department of Diagnostic ImagingSt. Jude Children’s Research HospitalMemphisUSA
  2. 2.Department of RadiologyKing’s College HospitalLondonUK
  3. 3.Department of RadiologyHeim Pal Children’s HospitalBudapestHungary

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