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Antimycobacterial and Antiplasmodial Compounds Produced by Endophytic Fungi: An Overview

  • Mariana Costa Ferreira
  • Camila Rodrigues de Carvalho
  • Carlos Leomar Zani
  • Luiz Henrique RosaEmail author
Chapter
Part of the Fungal Biology book series (FUNGBIO)

Abstract

The search for new compounds that may be used in the treatment of such diseases as malaria and tuberculosis is essential. Malaria is an infectious disease caused by the genus Plasmodium and affects approximately 212 million people around the world. Tuberculosis is an equally deadly infectious disease caused mainly by Mycobacterium tuberculosis affecting 8.8 million people around the world in 2010. Endophytic microorganisms, those residing asymptomatically within plant tissues, include a high diversity of species associated with different plants around the world and have been studied for their ability to produce different bioactive secondary metabolites having significant potential against neglected diseases. These metabolites are vivid examples of an extraordinary range of molecular diversity, built from a variety of different biosynthetic pathways modulated by the environment, and a plethora of ecological and chemical interactions takes place between endophytes and their host. This chapter presents a vanguard overview of the potential of endophytic fungi as producers of metabolites with antimycobacterial and antiplasmodial activities.

Abbreviations

ACT

Artemisinin-based combination therapy

AIDS

Acquired immunodeficiency syndrome

EC50

Half maximal effective concentration

IC50

Half maximal inhibitory concentration

MDR

Multi drug-resistant

MIC

Minimum inhibitory concentration

mL

Milliliters

WHO

World Health Organization

μg

Microgram

μM

Micromolar

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Mariana Costa Ferreira
    • 1
  • Camila Rodrigues de Carvalho
    • 2
  • Carlos Leomar Zani
    • 2
  • Luiz Henrique Rosa
    • 1
    Email author
  1. 1.Department of MicrobiologyFederal University of Minas GeraisBelo HorizonteBrazil
  2. 2.Laboratório de Química de Produtos Naturais BioativosFundação Oswaldo Cruz-Fiocruz, Instituto René RachouBelo HorizonteBrazil

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