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Terpenoids: An Activator of “Fuel-Sensing Enzyme AMPK” with Special Emphasis on Antidiabetic Activity

  • Smitha Grace S. R. 
  • Girish Chandran
  • Jyoti Bala Chauhan
Chapter

Abstract

The past decade has witnessed a tremendous resurgence in the interest and use of medicinal plants. The therapeutic effects of these medicinal plants can justifiably be attributed to the phytochemicals in them especially the flavonoids, alkaloids, sterols, terpenoids, phenolic acids, stilbenes, lignans, tannins, and saponins. Terpenoids comprise one of the most interesting groups of natural products; due to their diverse pharmacological activities, such compounds can either be used directly as active compounds or modified to increase their selectivity and potency.

Type 2 diabetes is one of the fastest-growing public health problems worldwide characterized by the abnormal glucose and lipid metabolism due in part to resistance to the actions of insulin in the skeletal muscle, liver, and fat. This may result from inadequate adaptation to environmental changes (e.g., imbalance between energy intake and energy expenditure). AMP-activated protein kinase (AMPK), a phylogenetically conserved serine/threonine protein kinase, acts as an integrator of regulatory signals monitoring systemic and cellular energy status. The growing realization that AMPK regulates the coordination of anabolic (synthesis and storage of glucose and fatty acids) and catabolic (oxidation of glucose and fatty acids) metabolic processes represents an attractive therapeutic target for intervention in many conditions of disordered energy balance. Recent evidences that pharmacological activation of AMPK improves blood glucose homeostasis, lipid profile, and blood pressure in insulin-resistant rodents make this protein kinase a novel therapeutic target in the treatment of type 2 diabetes. The present review provides updates on wide range of biological activities of terpenoids in activating AMPK and thereby regulating type 2 diabetes.

Keywords

Terpenoids Protein kinase Regulatory signal Glucose homeostasis 

Notes

Conflict of Interest

The authors do not have any conflict of interest to declare.

References

  1. Clark AM (1996) Natural Products As A Resource For New Drugs. Pharm Res 13(8):1133–1141CrossRefGoogle Scholar
  2. Gonzalez-Castejon M, Rodriguez-Casado A (2011) Dietary phytochemicals and their potential effects on obesity: A review. Pharmacol Res 64:438–455CrossRefGoogle Scholar
  3. Goto T, Takahashi N, Hirai S, Kawada T (2010) Various terpenoids derived from herbal and dietary plants function as ppar modulators and regulate carbohydrate and lipid metabolism. PPAR Res 2010:9CrossRefGoogle Scholar
  4. Huh YH, King J, Cohen J, Sherley JL (2011) SACK-expanded hair follicle stem cells display asymmetric nuclear Lgr5 expression with non-random sister chromatid segregation. Sci Rep 1:176. https://doi.org/10.1038/srep00176
  5. Kim IY, He Y-Y (2013) Targeting the AMP-activated protein kinase for cancer prevention and therapy. Front Oncol 3:2Google Scholar
  6. Koehn FE, Carter GT (2005) The evolving role of natural products in drug discovery. Nat Rev Drug Discov 4:206–220CrossRefGoogle Scholar
  7. Marín-Aguilar F, Pavillard LE, Giampieri F, Bullón P, Cordero MD (2017) Adenosine monophosphate (AMP)-activated protein kinase: a new target for nutraceutical compounds. Int J Mol Sci 18:288CrossRefGoogle Scholar
  8. Misra P, Chakrabarti R (2007) The role of AMP kinase in diabetes. Indian J Med Res 125:389–398PubMedGoogle Scholar
  9. Nasir Uddin M, Sharma G, Choi HS, Lim S-IL, Oh WK (2013) AMPK activators from natural products: a patent review. Nat Prod Sci 19(1):1–7Google Scholar
  10. Murase T, Misawa K, Haramizu S, Minegishi Y, Hase, T (2010) Nootkatone, a characteristic constituent of grapefruit, stimulates energy metabolism and prevents diet-induced obesity by activating AMPK. Am J Physiol-Endoc M299:E266–E275CrossRefGoogle Scholar
  11. Park IJ, Hwang JT, Kim YM, Ha J, Park OJ (2006). Differential modulation of AMPK signaling pathways by low or high levels of exogenous reactive oxygen species in colon cancer cells. Ann NY Acad Sci 1091:102–109CrossRefGoogle Scholar
  12. Phillipson JD (2001) Phytochemistry and medicinal plants. Phytochemistry 56:237–243CrossRefGoogle Scholar
  13. Saxena M, Saxena J, Nema R, Singh D, Gupta A (2013) Phytochemistry of medicinal plants. J Pharmacogn Phytochem 1(6):168–182Google Scholar
  14. Squirrell D (1999) SpR ophthalmology Royal Hallamshire Hospital Sheffield. Judith Bush General Practitioner and clinical assistant in Ophthalmology , Diabetes Mellitus, 31-33. Environ Health Perspect 107:783–789Google Scholar
  15. Yadava N, Yadava R, Goyalb A (2014) Chemistry of terpenoids. Int J Pharm Sci Rev Res 27(2):272–278Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Smitha Grace S. R. 
    • 1
  • Girish Chandran
    • 1
  • Jyoti Bala Chauhan
    • 2
  1. 1.Department of Studies in BiotechnologyPooja Bhagavat Memorial Mahajana Education Centre, Post Graduate Wing of SBRR Mahajana First Grade CollegeMysuruIndia
  2. 2.DOS in Biotechnology, Microbiology & BiochemistryPooja Bhagavat Memorial Mahajana Education Centre, Post Graduate Wing of SBRR Mahajana First Grade CollegeMysuruIndia

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