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Vitamin E

  • Umaiyal Munusamy
  • Siti Nor Akmar Abdullah
Chapter

Abstract

Vitamin E is a fat-soluble vitamin that consists of four different tocopherol and tocotrienol isomers (α, β, γ and δ). Homogentisate phytyltransferase (HPT) catalyses the condensation of homogentisate (HGA) and phytyl diphosphate (PDP). The HGA serves as precursors for the synthesis of tocopherols, tocotrienols and also plastoquinol-9 (PQ-9) in chloroplasts of plants. The condensation of PDP and HGA by HPT will produce intermediate product for tocopherol production. In addition, condensation of HGA and geranylgeranyl diphosphate (GGDP) by homogentisate geranylgeranyl transferase (HGGT) will produce tocotrienols. Meanwhile, tocopherol cyclase forms the chromanol head group of the various tocopherol and tocotrienol isomers. Medical evidence suggests that vitamin E especially α-tocotrienol which can be found in seeds and cereal grains protects the cells against cancer, strong antioxidant and an effective neuroprotector.

Keywords

Vitamin E Tocopherol Tocotrienol Homogentisate phytyltransferase (HPT) Tocopherol cyclase (TC) Antioxidant Cancer 

Abbreviations

DMPBQ

2-methyl-6-phytylbenzoquinol

DMGGBQ

2, 3-dimethyl-5-geranylgeranyl benzoquinol

GGDP Reductase

geranylgeranyl diphosphate reductase

GGDP

Geranylgeranyl diphosphate

HGA

Homogentisate

HGGT

Homogentisate geranylgeranyl transferase

HPP

p-hydroxyphenylpyruvate

HPPD

p-hydroxyphenolpyruvate dioxygenase

HPT

Homogentisate phytyltransferase

MGGBQ

2-Methyl-6-geranylgeranylbenzoquinol

PDP

Phytyl diphosphate

PQ-9

Plastoquinol-9

PrBQMT

2-methyl-6-prenylbenzoquinol methyltransferase

TC

Tocopherol cyclase

γ-TMT

Gamma-tocopherol methyltransferase

References

  1. Abbasi AR, Hajirezaei M, Hofius D, Sonnewald U, Voll LM (2007) Specific roles of α and γ tocopherol in abiotic stress responses of transgenic tobacco. Plant Physiol 143:1720–1738PubMedPubMedCentralCrossRefGoogle Scholar
  2. Abushita AA, Hebshi EA, Daood HG, Biacs PA (1997) Determination of antioxidant vitamins in tomatoes. Food Chem 60:207–212CrossRefGoogle Scholar
  3. Abutarbush SM, Radostits OM (2003) Congenital nutritional muscular dystrophy in a beef calf. Can Vet J 44:738–739PubMedPubMedCentralGoogle Scholar
  4. Adzim Khalili NAH, Rokiah MY, Asmah R, Siti Muskinah M, Abdum Manaf A (2010) Determination of radical scavenging activity and Vitamin A, C and E in organically grown Red Pitaya (Hylocereus sp.). Int Food Res J 17:405–409Google Scholar
  5. Arita M, Nomura K, Arai H, Inoue K (1997) Alpha-tocopherol transfer protein stimulates the secretion of alpha-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway. Proc Natl Acad Sci U S A 94(23):12437–12441PubMedPubMedCentralCrossRefGoogle Scholar
  6. Asensi-Fabado MA, Munne-Bosch S (2010) Vitamins in plants: occurrence, biosynthesis and antioxidant. Trends Plant Sci 15:582–592PubMedCrossRefGoogle Scholar
  7. Azzi A (2004) The role of α-tocopherol in preventing disease. Eur J Nutr 43:18–25CrossRefGoogle Scholar
  8. Azzi A, Ricciarelli R, Zing JM (2002) Non-antioxidant molecular functions of α-tocopherol (vitamin E). FEBS Lett 519:8–10PubMedCrossRefGoogle Scholar
  9. Azzi A, Stocker A (2000) Vitamin E: non-antioxidant roles. Prog Lipid Res 39:231–255PubMedCrossRefGoogle Scholar
  10. Bardhan J, Chakraborty R, Raychaudhuri U (2011) The 21st century form of vitamin E--tocotrienol. Curr Pharm Des 17:2196–2205PubMedCrossRefGoogle Scholar
  11. Barella L, Muller PY, Schlachter M, Hunziker W, Stocklin E, Spitzer V, Meier N, de Pascual-Teresa S, Minihane AM, Rimbach G (2004) Identification of hepatic molecular mechanisms of action of alpha-tocopherol using global gene expression profile analysis in rats. Biochim Biophys 1689:66–74CrossRefGoogle Scholar
  12. Bermudez Y, Ahmadi S, Lowel NE, Kruk PA (2007) Vitamin E suppresses telomerase activity in ovarian cancer cells. Cancer Detection Prev 31:119–128CrossRefGoogle Scholar
  13. Bonnie TYP, Choo YM (2000) Valuable minor constituents of commercial red palm olein: carotenoids, vitamin E, ubiquinones and sterols. J Oil Palm Res 12:14–24Google Scholar
  14. Bradford A, Atkinson J, Fuller N, R and RP (2003) The effect of vitamin E on structure of membrane lipid assemblies. J Lipid Res 44:1940–1945PubMedCrossRefGoogle Scholar
  15. Brigelius-Flohe R, Traber MG (1999) Vitamin E: function and metabolism. FASEB J 13:1145–1155PubMedCrossRefGoogle Scholar
  16. Campbell SE, Whaley SG, Phillips R, Aggarwal BB, Stimmel JB, Leesnitzer L, Blanchard SG, Stone WL, Christian M, Krishnan K (2008) Gamma tocotrienol and prostate cancer: the regulation of two independent pathways to potentiate cell growth inhibition and apoptosis. J Oil Palm Res:33–43Google Scholar
  17. Catoni C, Peters A, Schaefer MH (2008) Life history trade-offs are influenced by the diversity, availability and interactions of dietary antioxidants. Anim Behav 76:1107–1119CrossRefGoogle Scholar
  18. Cha-Sook Y, Timothy JS, Joy ES, Robert SP (2005) Long-chain carboxychromanols are the major metabolites of tocopherols and tocotrienols in A549 lung epithelial cells but not HepG2 cells. J Nutrition 135:227–232CrossRefGoogle Scholar
  19. Chen MH, Bergman CJ (2005) A rapid procedure for analyzing rice bran tocopherol, tocotrienol and γ-oryzanol contents. J Food Compos Anal 18:139–151CrossRefGoogle Scholar
  20. Chen S, Li H, Liu G (2006) Progress of vitamin E metabolic engineering in plants. Transgenic Res 15:655–665PubMedCrossRefGoogle Scholar
  21. Cheng Z, Sattler S, Maeda H, Sakuragi Y, Bryant DA, DellaPenna D (2003) Highly divergent methyltransferase catalyze reaction in tocopherol and plastoquinone synthesis in cyanobacteria and photosynthesis eukaryotes. Plant Cell 15:2343–2356PubMedPubMedCentralCrossRefGoogle Scholar
  22. Ching LS, Mohamed S (2001) Alpha tocopherol content in 62 edible tropical plants. J Agric Food Chem 49:3101–3105PubMedCrossRefGoogle Scholar
  23. Chun J, Lee J, Ye L, Exler J, Eitenmiller RR (2006) Tocopherol and tocotrienol contents of raw and processed fruits and vegetables in the United States diet. J Food Compos Anal 19:196–204CrossRefGoogle Scholar
  24. Collakova E, DellaPenna D (2001) Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis. Plant Physiol 127:1113–1124PubMedPubMedCentralCrossRefGoogle Scholar
  25. Collakova E, DellaPenna D (2003a) The role of homogentisate phytyltransferase and other tocopherol pathway enzymes in the regulation of tocopherol synthesis during abiotic stress. Plant Physiol 133:930–940PubMedPubMedCentralCrossRefGoogle Scholar
  26. Collakova E, DellaPenna D (2003b) Homogentisate Phytyltransferase activity is limiting for tocopherol biosynthesis in Arabidopsis. Plant Physiol 131:632–642PubMedPubMedCentralCrossRefGoogle Scholar
  27. Collin VC, Eymery F, Genty B, Rey P, Havaux M (2008) Vitamin E is essential for the tolerance of Arabidopsis thaliana to metal induced oxidative stress. Plant Cell Environ 31:244–257PubMedGoogle Scholar
  28. Corley RHV (2009) How much palm oil do we need? Environ Sci Policy 12:134–139CrossRefGoogle Scholar
  29. Crowell EF, McGrath JM, Douches DS (2008) Accumulation of vitamin E in potato (Solanum tuberosum) tubers. Transgenic Res, 17:205-217PubMedCrossRefGoogle Scholar
  30. DellaPenna D (2005) A decade of progress in understanding vitamin E synthesis in plants. J Plant Physiol 162:729–737PubMedCrossRefGoogle Scholar
  31. Dormann P (2007) Functional diversity of tocochromanols in plants. Planta 225:269–276PubMedCrossRefGoogle Scholar
  32. Dudareva N, Pichersky E (2000) Metabolic engineering of plant volatiles. Curr Opin Biotechnol 19:1–9Google Scholar
  33. Duracevic SF, Dordevic J, Jasnic N, Dordevic I, Vujovic P, Cvijic G (2010) The influence of vitamin E supplementation on the oxidative status of rat liver. Arch Biol Sci Belgrade 62:677–681CrossRefGoogle Scholar
  34. Dutta A, Singh M (2011) Comparative analysis of aqueous extracts of amaranth and coriander in scavenging free radical activity and protection of DNA against oxidative damage. Chiang Mai J Sci 38:560–571Google Scholar
  35. Endrigkeit J, Wang X, Cai D, Zhang C, Long Y, Meng J, Jung C (2009) Genetic mapping, cloning and functional characterization of the BnaX.VTE4 gene encoding a γ-tocopherol methyltransferase from oilseed rape. Theor Appl Genet 119:567–575PubMedCrossRefGoogle Scholar
  36. Evans WJ (2000) Vitamin E, vitamin C, and exercise. Am J Clin Nutr 72:647s–652sPubMedCrossRefGoogle Scholar
  37. Evans HM, Bishop KS (1922) On the existence of a hitherto unrecognized dietary factor essential for reproduction. Science 56:650–651PubMedCrossRefGoogle Scholar
  38. Fernholz E (1938) On the constitution of α-tocopherol. J Am Chem Soc 60:700–705CrossRefGoogle Scholar
  39. Fryer MJ (1992) The antioxidant effects of thylakoid vitamin E (α-tocopherol). Plant Cell Environ 15:381–392CrossRefGoogle Scholar
  40. Fujita T, Ogbonna JC, Tanaka H, Aoyagi H (2009) Effects of reactive oxygen species on α-tocopherol production in mitochondria and chloroplasts of Euglena gracilis. J Appl Phycol 21:185–191CrossRefGoogle Scholar
  41. Gasior R, Pieszka M, Brzoska F (2009) Validation of a method or simultaneous determination of tocopherols and tocotrienols in cereals using normal phase HPLC. J Anim Feed Sci 18:173–192CrossRefGoogle Scholar
  42. Gomez-Caravaca AM, Verardo V, Caboni MF (2010) Chromatographic techniques for the determination of alkyl-phenols, tocopherols and other minor polar compounds in raw and roasted cold pressed cashew. J Chromatogr A 1217:7411–7417PubMedCrossRefGoogle Scholar
  43. Gonzalez R, Collado JA, Nell S, Briceno J, Tamayo MJ, Fraga E, Bernardos A, Lopez-Cillero P, Pascussi JM, Rufian S, Vilarem MJ, De la Mata M, Brigelius-Flohe R, Maurel P, Muntane J (2007) Cytoprotective properties of alpha tocopherol are related to gene regulation in culture D-galactosamine-treated human hepatocytes. Free Radic Biol Med 43:1439–1452PubMedCrossRefGoogle Scholar
  44. Gopala Krishna AG, Prabhakar JV, Aitzetmuller K (1997) Tocopherol and fatty acid composition of some Indian pulses. JAOCS 74:1603–1606CrossRefGoogle Scholar
  45. Gray NA (1996) Vitamin E: hype or hope. Orthop Nurs 15:55–57PubMedGoogle Scholar
  46. Hass CG, Tang S, Leonard S, Traber MG, Miller JF, Knapp SJ (2006) Three non-allelic epistatically interacting methyltransferase mutations produce novel tocopherol (vitamin E) profiles in sunflower. Theor Appl Genet 113:767–782PubMedCrossRefGoogle Scholar
  47. Havaux M, Eymery F, Porfirova S, Rey P, Dormann P (2005) Vitamin E protects against photoinhibition and photooxidative stress in Arabidopsis thaliana. Plant Cell 17:3451–3469PubMedPubMedCentralCrossRefGoogle Scholar
  48. Hill KE, Motley AK, Li X, May JM, Burk RF (2001) Combined selenium and vitamin E deficiency causes fatal myopathy in Guinea pigs. Nutr Interact Toxic 131:1798–1802Google Scholar
  49. Horvath G, Wessjohann L, Bigirimana J, Jansen M, Guisez Y, Caubergs R, Horemans N (2006) Differential distribution of tocopherols and tocotrienols in photosynthetic and non-photosynthetic tissues. Phytochemistry 67:1185–1195PubMedCrossRefGoogle Scholar
  50. Horvath G, Wessjohann L, Bigirimana J, Monica H, Jansen M, Guisez Y, Caubergs R, Horemans N (2006) Accumulation of tocopherols and tocotrienols during seed development of grape (Vitis vinifera L. cv Albert Lavalle). Plant Physiol Biochem 44:724–731 http://www.scienceclarified.comPubMedCrossRefGoogle Scholar
  51. Huang CH, Higgs DA, Balfry SK, Devlin RH (2004) Effect of dietary vitamin E level on growth, tissue lipid peroxidation, and erythrocyte fragility of transgenic coho salmon, Oncorhynchus kisutch. Comp Biochem Physiol Part A 139:199–204CrossRefGoogle Scholar
  52. Hunter SC, Cahoon EB (2007) Enhancing vitamin E in oilseeds: unravelling tocopherol and tocotrienol biosynthesis. Lipids 42:97–108PubMedCrossRefGoogle Scholar
  53. Imsanguan P, Roaysubtawee A, Borirak R, Pongamphai S, Douglas S, Douglas PL (2008) Extraction of α-tocopherol and γ-oryzanol from rice bran. Food Sci Technol 41:1417–1424Google Scholar
  54. Johnson EA, Shvedova AA, Kisin E, O’Callaghan JP, Kommineni C, Miller DB (2002) d-MDMA during vitamin E deficiency: effects on dopaminergic neurotoxicity and hepatotoxicity. Brain Res 19:150–163CrossRefGoogle Scholar
  55. Joseph JA, Shukitt-Hale B, Denisova NA, Prior RL, Cao G, Martin A, Tagilalatela G, Bickford PC (1998) Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioural deficits. J Neurosci 18:8047–8055PubMedCrossRefGoogle Scholar
  56. Kaempf DE, Linderkamp O (1998) Do healthy premature infants fed breast milk need vitamin E supplementation: alpha-and gamma-tocopherol levels in blood components and buccal mucosal cells. Pediatr Res 44:54–59PubMedCrossRefGoogle Scholar
  57. Kang J, Pervaiz S (2012) Mitochondria: redox metabolism and dysfunction. Biochem Res Int 14:1–14CrossRefGoogle Scholar
  58. Kinen MM, Kamal-Eldin A, Lampi AM, Hopia A (2000) Effects of α and γ-tocopherols on formation of hydroperoxides and two decomposition products from methyl linoleate. JAOCS 77:801–806CrossRefGoogle Scholar
  59. Koch M, Arango Y, Mock HP, Heise KP (2002) Factors influencing α-tocopherol synthesis in pepper fruits. J Plant Physiol 159:1015–1019CrossRefGoogle Scholar
  60. Kositamongkol S, Suthutvoravut U, Chongviriyaphan N, Feungpean B, Nuntnarumit P (2011) Vitamin A and E status in very low birth weight infants. J Perinatol 31:471–476PubMedCrossRefGoogle Scholar
  61. Kruk J, Szymanska R, Krupinska K (2008) Tocopherol quinone content of green algae and higher plants revised by a new high-sensitive fluorescence detection method using HPLC-effects of high light stress and senescence. J Plant Physiol 165:1238–1247PubMedCrossRefGoogle Scholar
  62. Kumar R, Raclaru M, Schubeler T, Gruber J, Sadre R, Luhs W, Zarhloul KM, Freidt W, Enders D, Frentzen M, Weier D (2005) Characterisation of plant tocopherol cyclase and their overexpression in transgenic Brassica napus seeds. FEBS Lett 579:1357–1364PubMedCrossRefGoogle Scholar
  63. Lau HLN, Choo YM, Ma AN, Chuah CH (2008) Selective extraction of palm carotene and vitamin E from fresh palm-pressed mesocarp fiber (Elaeis guineensis) using supercritical CO2. J Food Eng 84:289–296CrossRefGoogle Scholar
  64. Lee K, Lee SM, Park SR, Jung J, Moon JK, Cheong JJ, Kim M (2007) Overexpression of Arabidopsis homogentisate phytyltransferase or tocopherol cyclase elevates vitamin E content by increasing gamma tocopherol level in lettuce (Lactuca sativa L.). Mol Cells 24:301–306PubMedGoogle Scholar
  65. Leong LP, Shui G (2002) An investigation of antioxidant capacity of fruits in Singapore markets. Food Chem 76:69–75CrossRefGoogle Scholar
  66. Ling MT, Luk SU, Al-Ejeh F, Khanna KK (2012) Tocotrienol as a potential anticancer agent. Carcinogenesis 33:233–239PubMedCrossRefGoogle Scholar
  67. Marsin Sanagi M, Abu Naim A, Hussain A, Siregar SH, Sarjadi MS, Abd Aziz N (2006) Development and application of new modified Poly(styrene-divinylbenzene) adsorbents and chromatography stationary phases IRPA Project Number 09-02-06-0074-EA2. 111:1–246Google Scholar
  68. Mcdowell LR, Williams SN, Hidiroglou N, Njeru CA, Hill GM, OchoA L, Wilkinson NS (1996) Vitamin E supplementation for the ruminant. Anim Feed Sci Technol 60:273–296CrossRefGoogle Scholar
  69. Misuna S, Swatsitang P, Jogloy S (2008) Fatty acids content and antioxidant capacity of peanut. KKU Scie J. 36:64–74Google Scholar
  70. Miyazawa T, Shibata A, Sookwong P, Kawakami Y, Eitsuka TT, Asai A, Oikawa S, Nakagawa K (2009) Antiangiogenic and anticancer potential on unsaturated vitamin E (tocotrienol). J Nutr Biochem 20:79–86PubMedCrossRefGoogle Scholar
  71. Mohammed HO, Divers TJ, Summers BA, de Lhunta A (2007) Vitamin E deficiency and risk of equine motor neuron disease. Acta Vet Scand 49(1):17PubMedPubMedCentralCrossRefGoogle Scholar
  72. Muir WI, Husband AL, Bryden WL (2002) Dietary supplementation with vitamin E modulates avian intestinal immunity. Br J Nutr 87:579–585PubMedCrossRefGoogle Scholar
  73. Nesaretnam K, Ambra R, Selvaduray KR, Radhakrishnan A, Reimann K, Razak G, Virgili F (2004) Tocotrienol-rich fraction from palm oil affects gene expression in tumors resulting from MCF-7 cell inoculation in athymic mice. Lipids 39:459–467PubMedCrossRefGoogle Scholar
  74. Nesaretnam K, Guthrie N, Chambers AF, Carrol KK (1995) Effects of tocotrienols on the growth of a human breast cancer cell line in culture. Lipids 30:1139–1143PubMedCrossRefGoogle Scholar
  75. Ng WK, Wang Y, Yuen KH (2008) Palm vitamin E for aquaculture feeds. J Oil Palm Res:1–7Google Scholar
  76. Nurniwalis AW, Suhaimi N, Siti Nor Akmar A, Mohamad Arif MA (2008) Gene discovery via expressed sequence tags from the oil palm (Elaeis guineensis Jacq.) mesocarp. J Oil Palm Res 20:87–96Google Scholar
  77. O’Sullivan MG, Byrne DV, Stagsted J, Andersen HJ, Martens M (2002) Sensory colour assessment of fresh meat from pigs supplemented with iron and vitamin E. Meat Sci 60:253–265PubMedCrossRefGoogle Scholar
  78. Oda SS, El-Maddawy ZK (2012) Protective effect of vitamin E and selenium combination on deltamethrin-induced reproductive toxicity in male rats. Exp Toxicol Pathol 64(7–8):813–819.  https://doi.org/10.1016/j.etp.2011.03.001CrossRefPubMedGoogle Scholar
  79. Oh MM, Carey EE, Rajashekar CB (2009) Environmental stresses induce health-promoting phytochemicals in lettuce. Plant Physiol Biochem 47:578–583PubMedCrossRefGoogle Scholar
  80. Oksman-Caldentey KM, Saito K (2005) Integrating genomics and metabolomics for engineering plant metabolic pathways. Curr Opin Plant Biol 16:174–179Google Scholar
  81. Ouahchi K, Arita M, Kayden H, Hentati F, Ben Hamida M, Sokol R, Arai H, Inoue K, Koenig M (1995) Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein. Nat Genet 9:141–145PubMedCrossRefGoogle Scholar
  82. Panahi M, Cheng X, Alli Z, Sardana R, Callaghan M, Phipps J, Altosaar I (2003) Plant derived recombinant human insulin like growth factor precursor prohormone IGF-1B caused differentiation of human neuroblastoma cell lines SH-SY5Y. Mol Breed 12:21–31CrossRefGoogle Scholar
  83. Patel V, Rink C, Khanna S, Sen CK (2011) Tocotrienols: the lesser known form of natural vitamin E. Indian J Exp Biol 49:732–738PubMedPubMedCentralGoogle Scholar
  84. Peretti N, Sassolas A, Roy CC, Deslanders C, Charcosset M, Castagnetti J, Pugnet-Chardon L, Moulin P, Labarge S, Bouthillier L, Lachaux A, Levy E (2010) Guidelines for the diagnosis and management of chylomicron retention disease based on a review of the literature and the experience of two centers. OJRD 5:1–13Google Scholar
  85. Porfirova S, Bergmuller E, Tropf S, Lemke R, Dormann P (2002) Isolation of an Arabidopsis mutant lacking vitamin E and identification of a cyclise essential for all tocopherol biosynthesis. PNAS 99:12495–12500PubMedCrossRefGoogle Scholar
  86. Pryor WA (2000) Vitamin E and hearth disease: basic science to clinical intervention trials. Free Radic Biol Med 28:141–164PubMedCrossRefGoogle Scholar
  87. Raclaru M, Gruber J, Kumar R, Sadre R, Luhs W, Karim Zarhloul M, Friedt W, Frentzen M, Weier D (2006) Increase of the tocochromanol content in transgenic Brassica napus seeds by overexpression of key enzymes involved in prenylquinone biosynthesis. Mol Breed 18:93–107CrossRefGoogle Scholar
  88. Ren W, Zhao L, Zhang L, Wang Y, Cui L, Tang Y, Sun X, Tang K (2011) Molecular analysis of a homogentisate phytyltransferase gene from Lactuca sativa L. Mol Biol Rep 38:1813–1819PubMedCrossRefGoogle Scholar
  89. Rimbach G, Moehring J, Huebbe P, Lodge JK (2010) Gene regulatory activity α-tocopherol. Molecules 15:1746–1761PubMedPubMedCentralCrossRefGoogle Scholar
  90. Rippert P, Scimemi C, Dubald M, Matringe M (2004) Engineering plant shikimate pathway for production of tocotrienol and improving herbicide resistance. Plant Physiol 134:1–9CrossRefGoogle Scholar
  91. Rocheford TR, Wong JC, Egesel CO, Lambert RJ (2002) Enhancement of vitamin E levels in corn. J Am College Nutr 21:191S–198SCrossRefGoogle Scholar
  92. Rodriguez Posada L, Shi J, Kakuda Y, Xue SP (2007) Extraction of tocotrienols from palm fatty acid distillates using molecular distillation. Sep Purif Technol 57:220–229CrossRefGoogle Scholar
  93. Ryynanen M, Lampi AM, Salo-Vaananen P, Ollilainen V, Piironen V (2004) A small scale sample preparation method with HPLC analysis for determination of tocopherols and tocotrienols in cereals. J Food Compos Anal 17:749–765CrossRefGoogle Scholar
  94. Sachdev P, Saharov T, Cathcart S (1999) The preventative role of antioxidants (Selegiline and vitamin E) in a rat model of tardive dyskinesia. Soc Biol Psychiatry 46:1672–1681CrossRefGoogle Scholar
  95. Sadre R, Gruber J, Frentzen M (2006) Characterization of homogentisate prenyltransferases involved in plastoquinone-9 and tocochromanol biosynthesis. FEBS Lett 580:5357–5362PubMedCrossRefGoogle Scholar
  96. Sakouhi F, Harrabi S, Absalon C, Sbei K, Boukhchina S, Kallel H (2008) α-Tocopherol and fatty acids contents of some Tunisian table olives (Olea europaea L.): changes in their composition during ripening and processing. Food Chem 108:833–839PubMedCrossRefGoogle Scholar
  97. Savidge B, Weiss JD, Wong YHH, Lassner MW, Mitsky TA, Shewmaker CK, Post-Beittenmiller D, Valentin HE (2002) Isolation and characterization of homogentisate phytyltransferase genes from Synechocystis sp. PCC 6803 and Arabidopsis. Plant Physiol 29:321–332CrossRefGoogle Scholar
  98. Schudel P, Mayer H, Metzger J, Ruegg R, Isler O (1963) Uber die Chemie des Vitamins E. Die Synthase von rac. All-trans-ζ1-ε- Tocopherol. Helv Chim Acta 46:2517–2526CrossRefGoogle Scholar
  99. Sen CK, Khanna S, Roy S (2007) Tocotrienols in health and disease: the other half of the natural vitamin E family. Mol Asp Med 28:692–728CrossRefGoogle Scholar
  100. Serafini M (2000) Dietary vitamin E and T cell-mediated function in the elderly: effectiveness and mechanism of action. Int J Dev Neurosci 18:401–410PubMedCrossRefGoogle Scholar
  101. Setiadi DH, Chass GA, Torday LL, Varro A, Papp JG (2003) Vitamin E: models. Shortened sidechain models of α, ß, γ and δ tocopherol and tocotrienol-a density functional study. J Mol Struc (Theochem) 637:11–26CrossRefGoogle Scholar
  102. Silva DHS, Pereira FC, Zanoni MVB, Yoshida M (2001) Lipophilic antioxidants from Iryanthera juruensis fruits. Phytochemistry 57:437–442PubMedCrossRefGoogle Scholar
  103. Sirikhachornkit A, Shin JW, Baroli I, Niyogi KK (2009) Replacement of α-tocopherol by β-tocopherol enhances resistance to Photooxidative stress in a xanthophyll-deficient strain of Chlamydomonas reinhardtii. Eukaryot Cell 8:1648–1657PubMedPubMedCentralCrossRefGoogle Scholar
  104. Sivakumar G, Bacchetta L, Gatti R, Zappa G (2005) HPLC screening of natural vitamin E from Mediterranean plant biofactories-a basic tool for pilot-scale bioreactors production of α-tocopherol. J Plant Physiol 162:1280–1283PubMedCrossRefGoogle Scholar
  105. Strzalka K, Szymanska R, Swiezewska E, Skorupinska-Tudek K, Suwalsky M (2009) Tocochromanols, plastoquinone and polyprenols in selected plant species from Chilean Patagonia. Acta Biol Cracoviensia Series Botanica 51:39–44Google Scholar
  106. Sundl M, Murkovic M, Bandoniene D, Winklhofer-Roob BM (2007) Vitamin E content of foods: comparison of result obtained from food composition tables and HPLC analysis. Clin Nutr 26:145–153PubMedCrossRefGoogle Scholar
  107. Tan B (2005) Appropriated spectrum vitamin E and new perspective on demethyl tocopherols and tocotrienols. J Am Neutraceu Assoc 8:1–16Google Scholar
  108. Tian L, Della Penna D, Dixon RA (2007) The pds2 mutation is a lesion in the Arabidopsis homogentisate solanesyltransferase gene involved in plastoquinone biosynthesis. Plant 226:1067–1073CrossRefGoogle Scholar
  109. Traber MG, Atkinson J (2007) Vitamin E, antioxidant and nothing more. Free Radic Biol Med 43:4–15PubMedPubMedCentralCrossRefGoogle Scholar
  110. Traber MG, Sies H (1996) Vitamin E in human: demand and delivery. Annu Rev Nutr 16:321–317PubMedCrossRefGoogle Scholar
  111. Ueda N, Suzuki Y, Rino Y, Takahashi T, Imada T, Takanashi Y, Kuroiwa Y (2009) Correlation between neurological dysfunction with vitamin E deficiency and gastrectomy. J Neurol Sci 287:216–220PubMedCrossRefGoogle Scholar
  112. Upritchard JE (2000) Effect of supplementation with tomato juice, vitamin E and vitamin CON LDL oxidations and products of inflammatory activity in type 2 diabetes. Diabetes Care 23:733–738PubMedCrossRefGoogle Scholar
  113. Venkatesh TV, Karunanandaa B, Free DL, Rottnek JM, Basziz SR, Valentin HE (2006) Identification and characterization of an Arabidopsis homogentisate phytyltransferase paralog. Planta 223:1134–1144PubMedCrossRefGoogle Scholar
  114. Viola V, Pilolli F, Piroddi M, Pierpaoli E, Orlando F, Provincialli M, Betti M, Mazzini F, Galli F (2011) Why tocotrienols work better: insights into the in vitro anticancer mechanism of vitamin E. Genes Nutr 7:29–41PubMedPubMedCentralCrossRefGoogle Scholar
  115. Voll LM, Abbasi AL (2007) Are there specific in vivo roles for α- and γ-tocopherol in plants? Plant Signal Behav 2:486–488PubMedPubMedCentralCrossRefGoogle Scholar
  116. Wan Omar WS, Willis LB, Rha C, Sinskey AJ, Ramli US, Mat Yunus AM, Ahmad Parveez GK, Sambanthamurthi R (2008) Isolation and utilization of acetyl-CoA carboxylase from oil palm (Elaeis guineensis) mesocarp. J Oil Palm Res 2:97–107Google Scholar
  117. Weber P, Bendich A, Machlin LJ (1997) Vitamin E and human health: rationale for determining recommended intake levels. Nutrition 13:450–460PubMedCrossRefGoogle Scholar
  118. Yang W, Cahoon RE, Hunter SC, Zhang C, Han J, Borgschulte T, Cahoon EB (2011) Vitamin E biosynthesis: functional characterization of the monocot homogentisate phytyltransferase. Plant J 65:206–217PubMedCrossRefGoogle Scholar
  119. Yoshida Y, Saito Y, Jones LS, Shigeri Y (2007) Chemical reactivities and physical effects in comparison between tocopherols and tocotrienols: physiological significance and prospects as antioxidants. J Biosci Bioeng 104:439–445PubMedCrossRefGoogle Scholar
  120. Zbierzak AM, Kanwischer M, Wille C, Vidi PA, Gravalisco P, Lohman A, Briesen I, Porfirova S, Brehelin C, Kessier F, Dormann P (2010) Intersection of the tocopherol and plastoquinol metabolic pathways at the plastoglobule. Biochem J 425:389–399CrossRefGoogle Scholar
  121. Zingg JM (2007) Modulation of signal transduction by vitamin E. Mol Asp Med 28:481–506CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Umaiyal Munusamy
    • 1
    • 2
  • Siti Nor Akmar Abdullah
    • 1
  1. 1.Institute of Plantation StudiesUniversiti Putra MalaysiaUPM, Serdang, SelangorMalaysia
  2. 2.Centre for Research in Biotechnology for Agriculture (CEBAR), Level 3, Research Management & Innovation ComplexUniversiti of MalayaKuala LumpurMalaysia

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