Infants and children with hyperinsulinism are at high risk of brain damage. Multiple studies have demonstrated the increased prevalence of both neurodevelopmental abnormalities (26–48%) and seizures (13–29%) in the hyperinsulinism population. Individuals are at risk of poor neurodevelopmental outcomes regardless of the duration of the hyperinsulinism or treatment modality. All children with hyperinsulinism require screening for developmental issues and swift intervention if abnormalities are identified.
KeywordsHyperinsulinism Hypoglycemia Developmental delay Seizures
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