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Pericyte Secretome

  • Abderahim Gaceb
  • Gesine Paul
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1109)

Abstract

The role of pericytes seems to extend beyond their known function in angiogenesis, fibrosis and wound healing, blood-brain barrier maintenance, and blood flow regulation. More and more data are currently accumulating indicating that pericytes, uniquely positioned at the interface between blood and parenchyma, secrete a large plethora of different molecules in response to microenvironmental changes. Their secretome is tissue-specific and stimulus-specific and includes pro- and anti-inflammatory factors, growth factors, and extracellular matrix as well as microvesicles suggesting the important role of pericytes in the regulation of immune response and immune evasion of tumors. However, the angiogenic and trophic secretome of pericytes indicates that their secretome plays a role in physiological homeostasis but possibly also in disease progression or could be exploited for regenerative processes in the future. This book chapter summarizes the current data on the secretory properties of pericytes from different tissues in response to certain pathological stimuli such as inflammatory stimuli, hypoxia, high glucose, and others and thereby aims to provide insights into the possible role of pericytes in these conditions.

Keywords

Pericytes Secretome Angiogenesis Inflammation Regeneration Blood-brain barrier Cytokines Chemokines Growth factor Microvesicles 

Abbreviations

AD

Alzheimer disease

AGE

Advanced glycation end product

Ang

Angiopoietin

BDNF

Brain-derived neurotrophic factor

CCL

Chemokine (C-C motif)

CD

Cluster of differentiation

CMV

Cytomegalovirus

COX-2

Prostaglandin-endoperoxide synthase 2

CXCL

Chemoattractants

EC

Endothelial cells

EGF

Endothelial growth factor

ENA

Epithelial-derived neutrophil-activating peptide

FGF

Fibroblast growth factor

G-CSF

Granulocyte colony-stimulating factor

GDNF

Glial cell-derived neurotrophic factor

GM-CSF

Granulocyte-macrophage colony-stimulating factor

GROα/β/γ

Growth-regulated protein alpha/beta/gamma

GUCY1B3

Guanylate cyclase 1 soluble beta3

HB-EGF

Heparin-binding EGF-like growth factor

HGF

Hepatocyte growth factor

HIF-1α

Hypoxia-inducible factor 1-alpha

HIV-1

Human immunodeficiency virus type-1

HLA

Human leukocyte antigen

HO-1

Heme oxygenase-1

ICAM

Intercellular adhesion molecule

IFN

Interferon

IGFPB

Insulin-like growth factor-binding protein

IL

Interleukin

iNOS

Induced nitric oxide synthase

IP-10

Interferon gamma-induced protein 10

ITAC

Interferon-inducible T-cell alpha chemoattractant

JE

Japanese encephalitis

LIF

Leukemia inhibitory factor

LPS

Lipopolysaccharide

MCP-1

Monocyte chemoattractant protein-1

MHC

Major histocompatibility complex

MIF

Macrophage migration inhibitory factor

MMP

Matrix metalloproteinases

MVs

Microvesicles

NGF

Nerve growth factor

NK

Natural killer

NO

Nitric oxide

NOX4

NADPH oxidase 4

NT3

Neurotrophin 3

PDGF

Platelet-derived growth factor

PGES

Prostaglandin E synthase

PLGF

Placental growth factor

RANTES

Regulated on activation normal T-cell expressed and secreted

ROS

Reactive oxygen species

SCF

Stem cell factor

SDF-1

Stromal cell-derived factor 1 alpha

SELE

Selectin E

TARC

Thymus- and activation-regulated chemokine

TGF

Transforming growth factor

TNF

Tumor necrosis factor

VCAM-1

Vascular cell adhesion protein

VEGF

Vascular endothelial growth factor

ZO1

Zona occludens 1

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© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Translational Neurology Group, Department of Clinical Sciences and Wallenberg Center for Molecular Medicine, Department of NeurologyLund UniversityLundSweden
  2. 2.Skåne University HospitalLundSweden

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