Solid Dose Formulations

  • Ajay Babu Pazhayattil
  • Naheed Sayeed-Desta
  • Emilija Fredro-Kumbaradzi
  • Jordan Collins
Part of the AAPS Introductions in the Pharmaceutical Sciences book series (AAPSINSTR)


Among the solid dosage forms, tablets and capsules take by far the largest fraction of drug products taken by oral route. The chapter discusses tablet and capsule formulations and the traditional manufacturing processes. New technologies such as 3D printing are currently emerging as an alternate manufacturing process. Continuous solid dose manufacturing utilizes technology such as process analytical technology (PAT), process modeling to enhance pharmaceutical solid dose manufacturing processes.


Formulation Solid dose Tablets Granulation Soft gelatin capsules Hard gelatin capsules 


  1. 1.
    Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy. Philadelphia: Lea & Febiger; 1970.Google Scholar
  2. 2.
    Hasegawa M. Direct compression microcrystalline cellulose grade 12 versus classic grade 102. Pharm Technol. 2002;26:50–61.Google Scholar
  3. 3.
    Block LH, Morreton A, Apte SP, Wendt RH, Munson EJ, Creekmore JR, Persaud IV, Sheehan C, Wang H. Excipients for direct compaction—an update. Pharm Dev Technol. 2009;11:111–24.Google Scholar
  4. 4.
    Shanmugham S. Granulation techniques and technologies: recent progresses. Bioimpacts. 2015;5(1):55–63.CrossRefGoogle Scholar
  5. 5.
    Acevedo D, Muliadi A, Giridhar A, Litster JD, Romañach RJ. Evaluation of three approaches for real-time monitoring of roller compaction with near-infrared spectroscopy. AAPS PharmSciTech. 2012;13(3):1005–12.CrossRefPubMedGoogle Scholar
  6. 6.
    Patil H, Tiwari RV, Repka MA. Hot-melt extrusion: from theory to application in pharmaceutical formulation. AAPS PharmSciTech. 2016;17(1):20–42.CrossRefGoogle Scholar
  7. 7.
    Teunou RE, Poncelet D. Batch and continuous fluid bed coating—review and state of the art. J Food Eng. 2002;53(4):325–40.CrossRefGoogle Scholar

Copyright information

© American Association of Pharmaceutical Scientists 2018

Authors and Affiliations

  • Ajay Babu Pazhayattil
    • 1
  • Naheed Sayeed-Desta
    • 2
  • Emilija Fredro-Kumbaradzi
    • 2
  • Jordan Collins
    • 3
  1. 1.Eurofins Alphora Reserach Inc. (Canada)TorontoCanada
  2. 2.Apotex (Canada)TorontoCanada
  3. 3.IQVIA (Canada)TorontoCanada

Personalised recommendations