Design and Characterization of Porous Collagen/Gelatin/Hydroxyethyl Cellulose Matrices Containing Microspheres Based on κ-Carrageenan
Polymeric microspheres have a wide range of medical and cosmetic applications and synthesis of these microparticles is the subject of numerous studies. The strategy of incorporating polymer microspheres into three-dimensional matrices to construct controlled-release materials have been attracting increased attention in recent years. The aim of this study was to obtain new materials by means of incorporating polymer microparticles (containing Calendula officinalis flower extract) in the three-dimensional polymer matrix with a porous structure. The microspheres were produced from κ-carrageenan, κ-carrageenan with addition of locust bean gum or sorbitol by extrusion and 2-phase emulsion methods. In the next step, microspheres were incorporated into a collagen/gelatin/hydroxyethyl cellulose matrix and materials were cross-linked using EDC/NHS mixture. The mechanical properties (Young’s modulus) of the obtained materials were characterized. The porous polymeric matrices combined with κ-carrageenan microparticles may become the basis for a new cosmetic or dermatological formulation. The size of the microparticles, their composition and quantity have a significant influence on their mechanical properties.
KeywordsMicrospheres Microencapsulation κ-carrageenan Calendula officinalis flower extract Polymeric matrices
Financial support from National Science Centre (NCN, Poland) Grant no. UMO-2016/21/D/ST8/01705 is gratefully acknowledged.
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