Chaperone-Like Proteins in Inflammation and Immunomodulation: Examples of Resistin and PPIases

  • Saurabh Pandey
  • Javeed Ahmad
  • Nasreen Zafar Ehtesham
Part of the Heat Shock Proteins book series (HESP, volume 16)


Hsp and other small proteins that function as an accessory chaperones interact with the cellular signaling network. They come up as an immediate response to stress when cells face the challenge of its own programmed death response. Chaperokines, with their inflammation and immune modulatory potential, try to strike the balance between recovery to normalcy and programmed death. Various disease pathways, environmental stresses, toxins and infections are the challenges that mount fatal stress. Resistin, an adipokine in murine model, small macrophage secreted protein in human and PPIases of Mycobacterium tuberculosis are the potential chaperokines. Though according to classical definition they do not fall under the category of HSP having α-crystalline domain, they function as small chaperone and are part of biological diversity where evolutionary conserved and adapted survival mechanisms work in parallel to protect and sustain life.


Chaperokine Heat shock protein Immunomodulation Inflammation PPIase Resistin 



Adenosine triphosphate


Adenylyl cyclase-associated protein 1



E. coli

Escherichia coli


Endoplasmic reticulum


FK506 binding protein


Forkhead Box P3


Human Resistin


Heat shock protein family


Heat shock proteins




Interferon regulatory factor 1


Mycobacterium tuberculosis


Macrophage infectivity potentiator


Nuclear factor of activated T cells


Nuclear factor kappa B


Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1


Peptidyl-prolyl cis/trans isomerases


Sodium dodecyl sulfate


Src homology 3


Toll-like receptors


Tumor necrosis factor


Regulatory T cells


Unfolded protein response


WD (Trp-Asp) or beta-transducin repeat motif



NZE would like to thank Centre of Excellence research grant (BT/PR12817/COE/34/23/2015) from the Department of Biotechnology, Ministry of Science and Technology (DBT), Government of India and research grant (No.5/9/1019/2011-RHN) from ICMR, Ministry of Health and Family welfare, Government of India for financial support.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Saurabh Pandey
    • 1
    • 2
  • Javeed Ahmad
    • 1
  • Nasreen Zafar Ehtesham
    • 1
  1. 1.Inflammation Biology and Cell Signaling LaboratoryNational Institute of PathologyNew DelhiIndia
  2. 2.Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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