Role of Chaperone Mediated Autophagy in Viral Infections
Chaperone-mediated autophagy (CMA) is a selective mechanism for degradation of soluble cytosolic proteins is responsible for the timed degradation of 30% of cytosolic proteins under conditions of prolonged nutrient deprivation and stress. Molecular chaperones in the lysosomal lumen and in the cytosol and induce this proteolytic pathway. A central molecule for CMA is a receptor in the lysosomal membrane is known as the lysosome-associated membrane protein (LAMP) type 2A. The decrease in CMA leads to cells to be more prone to oxidative stresses and pathogenes. Furthermore, the decreased CMA in aging is stem from reduced LAMP-2A in the lysosomal membrane. Here, we describe the evidence in support of the contribution of chaperokines and CMA in viral infections.
KeywordsAutophagy Chaperone Immunity Lysosome Misflolded proteins Viral infections
Hepatitis C virus
Heat shock proteins
Interferon α receptor 1
Lysosome-Associated Membrane Protein type 2A
PKR-like ER kinase
Unfolded protein response
Vesicular stomatitis virus
We would like to thank all members of virology department of Tarbiat Modares University and Hepatitis and AIDS department of Pasteur Institute for kind assistant and support.
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