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Role of Chaperone Mediated Autophagy in Viral Infections

  • Hoorieh SoleimanjahiEmail author
  • Asghar Abdoli
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 16)

Abstract

Chaperone-mediated autophagy (CMA) is a selective mechanism for degradation of soluble cytosolic proteins is responsible for the timed degradation of 30% of cytosolic proteins under conditions of prolonged nutrient deprivation and stress. Molecular chaperones in the lysosomal lumen and in the cytosol and induce this proteolytic pathway. A central molecule for CMA is a receptor in the lysosomal membrane is known as the lysosome-associated membrane protein (LAMP) type 2A. The decrease in CMA leads to cells to be more prone to oxidative stresses and pathogenes. Furthermore, the decreased CMA in aging is stem from reduced LAMP-2A in the lysosomal membrane. Here, we describe the evidence in support of the contribution of chaperokines and CMA in viral infections.

Keywords

Autophagy Chaperone Immunity Lysosome Misflolded proteins Viral infections 

Abbreviations

CHIP

Hsc70-interacting protein

CMA

Chaperone-mediated autophagy

HCV

Hepatitis C virus

HSP

Heat shock proteins

IFNLR1

Interferon α receptor 1

LAMP-2A

Lysosome-Associated Membrane Protein type 2A

PERK

PKR-like ER kinase

UPR

Unfolded protein response

VSV

Vesicular stomatitis virus

Notes

Acknowledgments

We would like to thank all members of virology department of Tarbiat Modares University and Hepatitis and AIDS department of Pasteur Institute for kind assistant and support.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Virology, Faculty of Medical SciencesTarbiat Modares UniversityTehranIran
  2. 2.Department of Hepatitis and AIDSPasteur Institute of IranTehranIran

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