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Heat Shock Protein 60: A Mediator of Atherosclerosis and Its Potential Therapeutic Role

  • Cecilia WickEmail author
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 16)

Abstract

Heat shock proteins (HSP) are highly conserved families of proteins expressed by a number of cell types following exposure to stressful environmental conditions in order to protect the cells from injury. The ability of a cell to withstand these environmental stresses is critical to its capacity to adapt and remain viable. Loss of this ability may lead to a pathological state. Abnormal localization, structure or function of HSP has been associated with different pathologies, including atherosclerosis. HSP60 has in particular been identified as playing important roles in inflammatory pathways and immune reactions in atherosclerosis. This chapter will highlight the role of HSP60 in atherosclerosis and the potential to target HSP60 or peptides thereof to alter the progression or even treat atherosclerosis.

Keywords

Atherosclerosis Autoimmunity Heat shock protein 60 Inflammation Regulatory T cells Tolerization 

Abbreviations

ACE

Acute coronary syndrome

AGE

Advanced glycation end product

APC

Antigen-presenting cell

ApoE−/−

Apolipoprotein E deficient

cHSP60

Chlamydia pneumonia heat shock protein 60

CVD

Cardiovascular disease

DC

Dendritic cell

GARP

Glycoprotein A representations predominant

GroEL

Human heat shock protein 60 produced in Escherichia coli

HCD

High cholesterol diet

hHSP60

Human heat shock protein 60

HSP

Heat shock protein

ICAM-1

Intracellular adhesion molecule-1

IFN

Interferon

IL

Interleukin

IMT

Inter media thickness

LAP

Latency associated peptide

LDL

Low-density lipoprotein

LDLr−/−

Low lipoprotein receptor deficient

LPS

Lipopolysaccharides

mbHSP65

Mycobacterial tuberculosis heat shock protein 65

MHC

Major histocompatibility complex

NO

Nitric oxid

oLDL

Oxidized low-density lipoprotein

PBMC

Peripheral blood mononuclear cells

RA

Rheumatoid arthritis

RAG1−/−

V(D)J recombination activation gene 1 deficient

rCTD

Rat C-terminal determinants

rHSP65

Rat heat shock protein 65

SCID

Severe combined immunodeficiency

sHSP60

Soluble heat shock protein 60

SLE

Systemic lupus erythematous

SMC

Smooth muscle cell

TGF

Transforming growth factor

TLR

Toll-like receptor

TNF

Tumor necrosis factor

Treg

Regulatory T cell

VCAM-1

Vascular cell adhesion molecule-1

Notes

Acknowledgements

I grateful to Professor em. Georg Wick, Laboratory of Autoimmunity, Section of Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria, for his kind help and valuable comments.

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Medicine, Unit of Rheumatology, Karolinska InstitutetKarolinska University Hospital Solna, Center for Molecular Medicine (CMM)StockholmSweden

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